ExoticRx · exoticrx.com/drugs/clorazepate
US brand names:Tranxene
Clorazepate is dosed at 0.5–2 mg/kg PO q8-12h in dogs, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.329 (2026-08-01).. Verify against current literature before clinical use.
Prodrug rapidly converted to desmethyldiazepam (nordiazepam) in acidic stomach. Enhances GABA-A receptor function.
DEA Schedule IV. Used as adjunctive anticonvulsant in dogs. Tolerance develops with chronic use. Taper to discontinue. Sedation, ataxia.
Species references:All Dog (Domestic) drugs
Controlled substance in the US
Controlled-drug status and schedules differ by country — check your local scheduling rules.
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 0.5–2 mg/kg | q8-12h | Moderate | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.329 (2026-08-01). |
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