Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Clorazepate is dosed at 0.5–2 mg/kg PO q8-12h in dogs, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.329 (2026-08-01).. Clorazepate is used in dogs for Adjunctive seizure control. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Clorazepate in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Tranxene
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.5–2 mg/kg | q8-12h | Long-term | Adjunctive seizure control | Moderate | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.329 (2026-08-01). |
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Prodrug rapidly converted to desmethyldiazepam (nordiazepam) in acidic stomach. Enhances GABA-A receptor function.
DEA Schedule IV. Used as adjunctive anticonvulsant in dogs. Tolerance develops with chronic use. Taper to discontinue. Sedation, ataxia.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Clorazepate dose range in dogs, with cited source references: PO 0.5–2 mg/kg q8-12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Clorazepate in dogs: PO.
Cited course lengths for Clorazepate in dogs include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Clorazepate is indicated in dogs for: Adjunctive seizure control.
These are general warnings for Clorazepate across species; consult the dog dosing table above for species-specific guidance. DEA Schedule IV. Used as adjunctive anticonvulsant in dogs. Tolerance develops with chronic use. Taper to discontinue. Sedation, ataxia.
Why a species-specific page? Clorazepate pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.