Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Clorazepate is dosed at 0.5–2 mg/kg PO q8-12h in dogs, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.329 (2026-08-01). — Plumb's 10th ed (held) printed p.301, Clorazepate monograph spanning p.301-302; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Clorazepate is used in dogs for Adjunctive seizure control. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Clorazepate in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Tranxene
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.5–2 mg/kg | q8-12h | Long-term | Adjunctive seizure control | Moderate | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.329 (2026-08-01). — Plumb's 10th ed (held) printed p.301, Clorazepate monograph spanning p.301-302; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.5–2 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.209 | • 0.5-2 mg/kg q8-12h PO, and as frequently as 4 hours. (Total dose is usually |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Prodrug rapidly converted to desmethyldiazepam (nordiazepam) in acidic stomach. Enhances GABA-A receptor function.
DEA Schedule IV. Used as adjunctive anticonvulsant in dogs. Tolerance develops with chronic use. Taper to discontinue. Sedation, ataxia.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Clorazepate dose range in dogs, with cited source references: PO 0.5–2 mg/kg q8-12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Clorazepate in dogs: PO.
Cited course lengths for Clorazepate in dogs include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Clorazepate is indicated in dogs for: Adjunctive seizure control.
These are general warnings for Clorazepate across species; consult the dog dosing table above for species-specific guidance. DEA Schedule IV. Used as adjunctive anticonvulsant in dogs. Tolerance develops with chronic use. Taper to discontinue. Sedation, ataxia.
Why a species-specific page? Clorazepate pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.