Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Doxepin is dosed at 3–5 mg/kg PO q12h in dogs, per Koch S, Torres S, Plumb DC. Small Animal Dermatology Drug Handbook. Ames, IA: Wiley-Blackwell; 2012.; Martin KM. Psychopharmacology - Which Drug and Why? Paper presented at: Wild West Veterinary Conference 2015. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.457 (2026-08-01).. Doxepin is used in dogs for Anxiety, allergic pruritus. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Doxepin in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Sinequan
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 3–5 mg/kg | q12h | Weeks to months | Anxiety, allergic pruritus | Moderate | Koch S, Torres S, Plumb DC. Small Animal Dermatology Drug Handbook. Ames, IA: Wiley-Blackwell; 2012.; Martin KM. Psychopharmacology - Which Drug and Why? Paper presented at: Wild West Veterinary Conference 2015. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.457 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits serotonin and norepinephrine reuptake. Also has potent antihistaminic (H1 and H2) and anticholinergic activity.
Used for anxiety, pruritus (potent antihistamine), and allergic dermatitis. Sedation common. Anticholinergic effects. Cardiac conduction effects — avoid with heart disease.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Doxepin dose range in dogs, with cited source references: PO 3–5 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Doxepin in dogs: PO.
Cited course lengths for Doxepin in dogs include: Weeks to months. Duration depends on the indication — match it to the specific dose rule in the table above.
Doxepin is indicated in dogs for: Anxiety, allergic pruritus.
These are general warnings for Doxepin across species; consult the dog dosing table above for species-specific guidance. Used for anxiety, pruritus (potent antihistamine), and allergic dermatitis. Sedation common. Anticholinergic effects. Cardiac conduction effects — avoid with heart disease.
Why a species-specific page? Doxepin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.