Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Doxepin is used in dog for Anxiety, allergic pruritus. Routes documented in dog: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Doxepin in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Sinequan
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 3–5 mg/kg | q12h | Weeks to months | Anxiety, allergic pruritus | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits serotonin and norepinephrine reuptake. Also has potent antihistaminic (H1 and H2) and anticholinergic activity.
Used for anxiety, pruritus (potent antihistamine), and allergic dermatitis. Sedation common. Anticholinergic effects. Cardiac conduction effects — avoid with heart disease.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Doxepin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.