Cat · Felis catus · typical adult weight 2.50–7.00 kg
Doxepin is dosed at 0.5–1 mg/kg PO q12h in cats, per Olivry T, Saridomichelakis M, International Committee on Atopic Diseases of A. Evidence-based guidelines for anti-allergic drug withdrawal times before allergen-specific intradermal and IgE serological tests in dogs. Vet Dermatol. 2013;24(2):225-e249. doi:10.1111/vde.12016 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.457 (2026-08-01). — Plumb's 10th ed (held) printed p.429, Doxepin monograph; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Doxepin is used in cats for Psychogenic alopecia. Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Doxepin in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Sinequan
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.5–1 mg/kg | q12h | Weeks to months | Psychogenic alopecia | Weak | Olivry T, Saridomichelakis M, International Committee on Atopic Diseases of A. Evidence-based guidelines for anti-allergic drug withdrawal times before allergen-specific intradermal and IgE serological tests in dogs. Vet Dermatol. 2013;24(2):225-e249. doi:10.1111/vde.12016 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.457 (2026-08-01). — Plumb's 10th ed (held) printed p.429, Doxepin monograph; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.5–1 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.154 | 0.5-1.0 mg/kg p.o. q12-24h. Doxorubicin (Adriamycin) (Doxorubicin*) POM |
| 0.5–1 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.300 | • 0.5-1 mg/kg q12-24h. Start with low dose initially. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Inhibits serotonin and norepinephrine reuptake. Also has potent antihistaminic (H1 and H2) and anticholinergic activity.
Used for anxiety, pruritus (potent antihistamine), and allergic dermatitis. Sedation common. Anticholinergic effects. Cardiac conduction effects — avoid with heart disease.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Doxepin dose range in cats, with cited source references: PO 0.5–1 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Doxepin in cats: PO.
Cited course lengths for Doxepin in cats include: Weeks to months. Duration depends on the indication — match it to the specific dose rule in the table above.
Doxepin is indicated in cats for: Psychogenic alopecia.
These are general warnings for Doxepin across species; consult the cat dosing table above for species-specific guidance. Used for anxiety, pruritus (potent antihistamine), and allergic dermatitis. Sedation common. Anticholinergic effects. Cardiac conduction effects — avoid with heart disease.
Why a species-specific page? Doxepin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.