Cat · Felis catus · typical adult weight 2.50–7.00 kg
Alprazolam is dosed at 0.0125–0.025 mg/kg PO q12h in cats, per Papich, Saunders Handbook of Veterinary Drugs, 4th ed, corpus p.49 = print p.21, Small Animal Dosage - Cats: '0.125 mg per cat q12h PO (half of 0.25-mg tablet) or 0.0125-0.025 mg/kg q12h PO, and up to q8h.'. Alprazolam is used in cats for Anxiety, urine spraying. Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Alprazolam in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Xanax
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.0125–0.025 mg/kg | q12h | Variable | Anxiety, urine spraying | Moderate | Papich, Saunders Handbook of Veterinary Drugs, 4th ed, corpus p.49 = print p.21, Small Animal Dosage - Cats: '0.125 mg per cat q12h PO (half of 0.25-mg tablet) or 0.0125-0.025 mg/kg q12h PO, and up to q8h.' |
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Enhances GABA-A receptor activity by binding benzodiazepine site, increasing chloride conductance. Anxiolytic, sedative, and anticonvulsant.
DEA Schedule IV. Paradoxical excitement possible in some animals. Hepatic metabolism. Dependence with chronic use — taper to discontinue. Cats: idiosyncratic hepatic necrosis (rare).
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Alprazolam dose range in cats, with cited source references: PO 0.0125–0.025 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Alprazolam in cats: PO.
Cited course lengths for Alprazolam in cats include: Variable. Duration depends on the indication — match it to the specific dose rule in the table above.
Alprazolam is indicated in cats for: Anxiety, urine spraying.
These are general warnings for Alprazolam across species; consult the cat dosing table above for species-specific guidance. DEA Schedule IV. Paradoxical excitement possible in some animals. Hepatic metabolism. Dependence with chronic use — taper to discontinue. Cats: idiosyncratic hepatic necrosis (rare).
Why a species-specific page? Alprazolam pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.