Cat · Felis catus · typical adult weight 2.50–7.00 kg
Fluoxetine is dosed at 0.5–1.5 mg/kg PO q24h in cats, per Papich, Saunders Handbook of Veterinary Drugs, 5th Ed, printed p.341 (corpus page 369), Fluoxetine Hydrochloride > Small Animal Dosage > Cats — EDITION CORRECTED 2026-08-07: this citation named the 5th edition, which is not held. The page locator resolves in the 4th ed (2016), the copy actually consulted, and that page names the drug; the reference is to the 4th. — SOURCE EDITION: Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855. Fluoxetine is used in cats for Urine marking, aggression, compulsive grooming. Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Fluoxetine in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Reconcile, Prozac
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.5–1.5 mg/kg | q24h | Long-term | Urine marking, aggression, compulsive grooming | Weak | Papich, Saunders Handbook of Veterinary Drugs, 5th Ed, printed p.341 (corpus page 369), Fluoxetine Hydrochloride > Small Animal Dosage > Cats — EDITION CORRECTED 2026-08-07: this citation named the 5th edition, which is not held. The page locator resolves in the 4th ed (2016), the copy actually consulted, and that page names the drug; the reference is to the 4th. — SOURCE EDITION: Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (mg/animal) | Route | Source | As printed |
|---|---|---|---|
| 0.5–4 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.369 | • 0.5-4 mg/cat q24h PO (0.5-1 mg/kg per day). Start with 1/4 tablet (2.5 mg) per cat, |
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.5–1 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.188 | 0.5-1.0 mg/kg p.o. q24h. |
| 0.5–1 |
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Selectively inhibits serotonin reuptake at the presynaptic membrane, increasing serotonergic neurotransmission.
Reconcile FDA-approved for canine separation anxiety. 4-6 weeks for full effect. Serotonin syndrome risk with tramadol, MAOIs, TCAs. Reduced appetite, lethargy initially. Long half-life.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Fluoxetine dose range in cats, with cited source references: PO 0.5–1.5 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Fluoxetine in cats: PO.
Cited course lengths for Fluoxetine in cats include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Fluoxetine is indicated in cats for: Urine marking, aggression, compulsive grooming.
These are general warnings for Fluoxetine across species; consult the cat dosing table above for species-specific guidance. Reconcile FDA-approved for canine separation anxiety. 4-6 weeks for full effect. Serotonin syndrome risk with tramadol, MAOIs, TCAs. Reduced appetite, lethargy initially. Long half-life.
Why a species-specific page? Fluoxetine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| PO |
| Papich Saunders Handbook of Veterinary Drugs, 4th edp.369 |
| • 0.5-4 mg/cat q24h PO (0.5-1 mg/kg per day). Start with 1/4 tablet (2.5 mg) per cat, |
| 1 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.369 | • Urine marking: 1 mg/kg q24h PO and increase to 1.5 mg/kg if there has been |
| 1.5 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.369 | • Urine marking: 1 mg/kg q24h PO and increase to 1.5 mg/kg if there has been |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.