Cat · Felis catus · typical adult weight 2.50–7.00 kg
Clomipramine is dosed at 0.25–0.5 mg/kg PO q24h in cats, per King JN, Steffan J, Heath SE, et al. Determination of the dosage of clomipramine for the treatment of urine spraying in cats. J Am Vet Med Assoc. 2004;225(6):881-887. doi:10.2460/javma.2004.225.881 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.318 (2026-08-01). — Plumb's 10th ed (held) printed p.289, Clomipramine monograph spanning p.289-291; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Clomipramine is used in cats for Urine spraying, anxiety. Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Clomipramine in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Clomicalm, Anafranil
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.25–0.5 mg/kg | q24h | Long-term | Urine spraying, anxiety | Moderate | King JN, Steffan J, Heath SE, et al. Determination of the dosage of clomipramine for the treatment of urine spraying in cats. J Am Vet Med Assoc. 2004;225(6):881-887. doi:10.2460/javma.2004.225.881 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.318 (2026-08-01). — Plumb's 10th ed (held) printed p.289, Clomipramine monograph spanning p.289-291; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.25–1 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.110 | 0.25-1 mg/kg p.o. q24h. |
| 0.5 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.203 | • 1-5 mg per cat q12-24h PO (0.5 mg/kg per day) and gradually increase. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
Need the exact dose for your patient?
These ranges are per kg. Enter your cat's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Potent serotonin and norepinephrine reuptake inhibitor. More serotonin-selective than amitriptyline. Also has anticholinergic properties.
FDA-approved for separation anxiety in dogs. 2-4 weeks for effect. GI upset, sedation, urinary retention. CONTRAINDICATED with MAOIs. Serotonin syndrome risk. Lower seizure threshold.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Clomipramine dose range in cats, with cited source references: PO 0.25–0.5 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Clomipramine in cats: PO.
Cited course lengths for Clomipramine in cats include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Clomipramine is indicated in cats for: Urine spraying, anxiety.
These are general warnings for Clomipramine across species; consult the cat dosing table above for species-specific guidance. FDA-approved for separation anxiety in dogs. 2-4 weeks for effect. GI upset, sedation, urinary retention. CONTRAINDICATED with MAOIs. Serotonin syndrome risk. Lower seizure threshold.
Why a species-specific page? Clomipramine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.