Cat · Felis catus · typical adult weight 2.50–7.00 kg
Clomipramine is dosed at 0.25–0.5 mg/kg PO q24h in cats, per King JN, Steffan J, Heath SE, et al. Determination of the dosage of clomipramine for the treatment of urine spraying in cats. J Am Vet Med Assoc. 2004;225(6):881-887. doi:10.2460/javma.2004.225.881 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.318 (2026-08-01).. Clomipramine is used in cats for Urine spraying, anxiety. Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Clomipramine in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Clomicalm, Anafranil
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.25–0.5 mg/kg | q24h | Long-term | Urine spraying, anxiety | Moderate | King JN, Steffan J, Heath SE, et al. Determination of the dosage of clomipramine for the treatment of urine spraying in cats. J Am Vet Med Assoc. 2004;225(6):881-887. doi:10.2460/javma.2004.225.881 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.318 (2026-08-01). |
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These ranges are per kg. Enter your cat's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Potent serotonin and norepinephrine reuptake inhibitor. More serotonin-selective than amitriptyline. Also has anticholinergic properties.
FDA-approved for separation anxiety in dogs. 2-4 weeks for effect. GI upset, sedation, urinary retention. CONTRAINDICATED with MAOIs. Serotonin syndrome risk. Lower seizure threshold.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Clomipramine dose range in cats, with cited source references: PO 0.25–0.5 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Clomipramine in cats: PO.
Cited course lengths for Clomipramine in cats include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Clomipramine is indicated in cats for: Urine spraying, anxiety.
These are general warnings for Clomipramine across species; consult the cat dosing table above for species-specific guidance. FDA-approved for separation anxiety in dogs. 2-4 weeks for effect. GI upset, sedation, urinary retention. CONTRAINDICATED with MAOIs. Serotonin syndrome risk. Lower seizure threshold.
Why a species-specific page? Clomipramine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.