Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Clomipramine is dosed at 1–3 mg/kg PO q12h in dogs, per Hewson CJ, Luescher UA, Parent JM, Conlon PD, Ball RO. Efficacy of clomipramine in the treatment of canine compulsive disorder. J Am Vet Med Assoc. 1998;213(12):1760-1766. doi:10.2460/javma.1998.213.12.1760 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.318 (2026-08-01).. Clomipramine is used in dogs for Separation anxiety, compulsive disorders. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Clomipramine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Clomicalm, Anafranil
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 1–3 mg/kg | q12h | Long-term (months) | Separation anxiety, compulsive disorders | Strong |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Potent serotonin and norepinephrine reuptake inhibitor. More serotonin-selective than amitriptyline. Also has anticholinergic properties.
FDA-approved for separation anxiety in dogs. 2-4 weeks for effect. GI upset, sedation, urinary retention. CONTRAINDICATED with MAOIs. Serotonin syndrome risk. Lower seizure threshold.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Clomipramine dose range in dogs, with cited source references: PO 1–3 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Clomipramine in dogs: PO.
Cited course lengths for Clomipramine in dogs include: Long-term (months). Duration depends on the indication — match it to the specific dose rule in the table above.
Clomipramine is indicated in dogs for: Separation anxiety, compulsive disorders.
These are general warnings for Clomipramine across species; consult the dog dosing table above for species-specific guidance. FDA-approved for separation anxiety in dogs. 2-4 weeks for effect. GI upset, sedation, urinary retention. CONTRAINDICATED with MAOIs. Serotonin syndrome risk. Lower seizure threshold.
Why a species-specific page? Clomipramine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.