Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Clomipramine is dosed at 1–3 mg/kg PO q12h in dogs, per Hewson CJ, Luescher UA, Parent JM, Conlon PD, Ball RO. Efficacy of clomipramine in the treatment of canine compulsive disorder. J Am Vet Med Assoc. 1998;213(12):1760-1766. doi:10.2460/javma.1998.213.12.1760 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.318 (2026-08-01). — Plumb's 10th ed (held) printed p.289, Clomipramine monograph spanning p.289-291; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Clomipramine is used in dogs for Separation anxiety, compulsive disorders. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Clomipramine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Clomicalm, Anafranil
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 1–3 mg/kg | q12h | Long-term (months) | Separation anxiety, compulsive disorders | Strong | Hewson CJ, Luescher UA, Parent JM, Conlon PD, Ball RO. Efficacy of clomipramine in the treatment of canine compulsive disorder. J Am Vet Med Assoc. 1998;213(12):1760-1766. doi:10.2460/javma.1998.213.12.1760 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.318 (2026-08-01). — Plumb's 10th ed (held) printed p.289, Clomipramine monograph spanning p.289-291; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 1–2 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.110 | 1-2 mg/kg p.o. q12h. |
| 1–3 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.203 | • 1-3 mg/kg/day q12h PO. Start at lower dose and gradually increase. Increases in |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Potent serotonin and norepinephrine reuptake inhibitor. More serotonin-selective than amitriptyline. Also has anticholinergic properties.
FDA-approved for separation anxiety in dogs. 2-4 weeks for effect. GI upset, sedation, urinary retention. CONTRAINDICATED with MAOIs. Serotonin syndrome risk. Lower seizure threshold.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Clomipramine dose range in dogs, with cited source references: PO 1–3 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Clomipramine in dogs: PO.
Cited course lengths for Clomipramine in dogs include: Long-term (months). Duration depends on the indication — match it to the specific dose rule in the table above.
Clomipramine is indicated in dogs for: Separation anxiety, compulsive disorders.
These are general warnings for Clomipramine across species; consult the dog dosing table above for species-specific guidance. FDA-approved for separation anxiety in dogs. 2-4 weeks for effect. GI upset, sedation, urinary retention. CONTRAINDICATED with MAOIs. Serotonin syndrome risk. Lower seizure threshold.
Why a species-specific page? Clomipramine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.