Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Imipramine is dosed at 2–4 mg/kg PO q12h in dogs, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.675 (2026-08-01). — Plumb's 10th ed (held) printed p.646, Imipramine monograph spanning p.646-648; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Imipramine is used in dogs for Separation anxiety, urinary incontinence. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Imipramine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Tofranil
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 2–4 mg/kg | q12h | Weeks | Separation anxiety, urinary incontinence | Moderate | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.675 (2026-08-01). — Plumb's 10th ed (held) printed p.646, Imipramine monograph spanning p.646-648; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 1–2 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.222 | 1-2 mg/kg p.o. q12h or 2-4 mg/kg p.o. q24h |
| 2–4 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.222 | 1-2 mg/kg p.o. q12h or 2-4 mg/kg p.o. q24h |
| 2–4 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.424 | • 2-4 mg/kg q12-24h PO. • 0.5-1 mg/kg q12-24h PO. |
| 0.5–1 | PO |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits serotonin and norepinephrine reuptake. Anticholinergic properties increase urethral sphincter tone.
Used for separation anxiety and urinary incontinence (increases sphincter tone). Cardiac arrhythmias at toxic doses. Sedation. Do not combine with MAO inhibitors.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Imipramine dose range in dogs, with cited source references: PO 2–4 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Imipramine in dogs: PO.
Cited course lengths for Imipramine in dogs include: Weeks. Duration depends on the indication — match it to the specific dose rule in the table above.
Imipramine is indicated in dogs for: Separation anxiety, urinary incontinence.
These are general warnings for Imipramine across species; consult the dog dosing table above for species-specific guidance. Used for separation anxiety and urinary incontinence (increases sphincter tone). Cardiac arrhythmias at toxic doses. Sedation. Do not combine with MAO inhibitors.
Why a species-specific page? Imipramine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| Papich Saunders Handbook of Veterinary Drugs, 4th edp.424 |
| • 2-4 mg/kg q12-24h PO. • 0.5-1 mg/kg q12-24h PO. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.