Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Imipramine is dosed at 2–4 mg/kg PO q12h in dogs, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.675 (2026-08-01).. Imipramine is used in dogs for Separation anxiety, urinary incontinence. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Imipramine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Tofranil
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 2–4 mg/kg | q12h | Weeks | Separation anxiety, urinary incontinence | Moderate | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.675 (2026-08-01). |
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Inhibits serotonin and norepinephrine reuptake. Anticholinergic properties increase urethral sphincter tone.
Used for separation anxiety and urinary incontinence (increases sphincter tone). Cardiac arrhythmias at toxic doses. Sedation. Do not combine with MAO inhibitors.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Imipramine dose range in dogs, with cited source references: PO 2–4 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Imipramine in dogs: PO.
Cited course lengths for Imipramine in dogs include: Weeks. Duration depends on the indication — match it to the specific dose rule in the table above.
Imipramine is indicated in dogs for: Separation anxiety, urinary incontinence.
These are general warnings for Imipramine across species; consult the dog dosing table above for species-specific guidance. Used for separation anxiety and urinary incontinence (increases sphincter tone). Cardiac arrhythmias at toxic doses. Sedation. Do not combine with MAO inhibitors.
Why a species-specific page? Imipramine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.