Imipramine for Dog
Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Imipramine is used in dog for Separation anxiety, urinary incontinence. Routes documented in dog: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Imipramine in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Tofranil
Dose ranges
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 2–4 mg/kg | q12h | Weeks | Separation anxiety, urinary incontinence | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Mechanism of action
Inhibits serotonin and norepinephrine reuptake. Anticholinergic properties increase urethral sphincter tone.
Side effects & warnings
Used for separation anxiety and urinary incontinence (increases sphincter tone). Cardiac arrhythmias at toxic doses. Sedation. Do not combine with MAO inhibitors.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Other Behavioral drugs with dog dosing
Why a species-specific page? Imipramine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.