ExoticRx · exoticrx.com/drugs/imipramine
Imipramine
Tofranil
Drug Class
Routes
Indications
Mechanism of Action
Inhibits serotonin and norepinephrine reuptake. Anticholinergic properties increase urethral sphincter tone.
Side effects & warnings
Used for separation anxiety and urinary incontinence (increases sphincter tone). Cardiac arrhythmias at toxic doses. Sedation. Do not combine with MAO inhibitors.
Species with Imipramine dosing data (1 dose rule)
Species references:All Dog (Domestic) drugs
Evidence levels across 1 dose rule
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Backed by a published source
- · Plumb's Veterinary Drug Handbook, 9th Ed
Sample dosing (1 of 1 cited rule)
A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 2–4 mg/kg | q12h | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
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Source citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.