ExoticRx · exoticrx.com/drugs/imipramine
US brand names:Tofranil
Imipramine is dosed at 2–4 mg/kg PO q12h in dogs, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.675 (2026-08-01).. Verify against current literature before clinical use.
Inhibits serotonin and norepinephrine reuptake. Anticholinergic properties increase urethral sphincter tone.
Used for separation anxiety and urinary incontinence (increases sphincter tone). Cardiac arrhythmias at toxic doses. Sedation. Do not combine with MAO inhibitors.
Species references:All Dog (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 2–4 mg/kg | q12h | Moderate | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.675 (2026-08-01). |
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