Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Duloxetine is dosed at 1–2 mg/kg PO q24h in dogs, per KuKanich B, JVIM 2013; Veterinary pain management review. Duloxetine is used in dogs for Neuropathic pain / anxiety. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Duloxetine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Cymbalta
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 1–2 mg/kg | q24h | Chronic use; taper to discontinue | Neuropathic pain / anxiety | Weak | KuKanich B, JVIM 2013; Veterinary pain management review |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Potent inhibitor of both serotonin and norepinephrine reuptake. Also used for neuropathic pain management due to descending inhibitory pathway modulation.
Do not combine with MAOIs or tramadol — risk of serotonin syndrome. May cause hepatotoxicity. GI upset common. Taper to discontinue.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Duloxetine dose range in dogs, with cited source references: PO 1–2 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Duloxetine in dogs: PO.
Cited course lengths for Duloxetine in dogs include: Chronic use; taper to discontinue. Duration depends on the indication — match it to the specific dose rule in the table above.
Duloxetine is indicated in dogs for: Neuropathic pain / anxiety.
These are general warnings for Duloxetine across species; consult the dog dosing table above for species-specific guidance. Do not combine with MAOIs or tramadol — risk of serotonin syndrome. May cause hepatotoxicity. GI upset common. Taper to discontinue.
Why a species-specific page? Duloxetine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.