Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Alprazolam is dosed at 0.01–0.1 mg/kg PO q4-12h as needed in dogs, per BSAVA Small Animal Formulary, 10th ed, Part A (Canine and Feline), corpus p.29 = print p.13: 'Dogs: For anxiolysis an initial dose within the range of 0.01-0.1 mg/kg p.o. as needed up to 4 times a day is recommended; the dose can be titrated up or down to the minimum effective dose, which may be below this level.' Frequency corroborated by Papich, Saunders Handbook of Veterinary Drugs 4th ed, corpus p.49 = print p.21: '0.025-0.1 mg/kg q8h PO. Administration more frequently (q4-6h) has been used in some patients.'. Alprazolam is used in dogs for Noise phobia, panic anxiety. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Alprazolam in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Xanax
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.01–0.1 mg/kg | q4-12h as needed | Situational use | Noise phobia, panic anxiety | Moderate | BSAVA Small Animal Formulary, 10th ed, Part A (Canine and Feline), corpus p.29 = print p.13: 'Dogs: For anxiolysis an initial dose within the range of 0.01-0.1 mg/kg p.o. as needed up to 4 times a day is recommended; the dose can be titrated up or down to the minimum effective dose, which may be below this level.' Frequency corroborated by Papich, Saunders Handbook of Veterinary Drugs 4th ed, corpus p.49 = print p.21: '0.025-0.1 mg/kg q8h PO. Administration more frequently (q4-6h) has been used in some patients.' |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Enhances GABA-A receptor activity by binding benzodiazepine site, increasing chloride conductance. Anxiolytic, sedative, and anticonvulsant.
DEA Schedule IV. Paradoxical excitement possible in some animals. Hepatic metabolism. Dependence with chronic use — taper to discontinue. Cats: idiosyncratic hepatic necrosis (rare).
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Alprazolam dose range in dogs, with cited source references: PO 0.01–0.1 mg/kg q4-12h as needed. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Alprazolam in dogs: PO.
Cited course lengths for Alprazolam in dogs include: Situational use. Duration depends on the indication — match it to the specific dose rule in the table above.
Alprazolam is indicated in dogs for: Noise phobia, panic anxiety.
These are general warnings for Alprazolam across species; consult the dog dosing table above for species-specific guidance. DEA Schedule IV. Paradoxical excitement possible in some animals. Hepatic metabolism. Dependence with chronic use — taper to discontinue. Cats: idiosyncratic hepatic necrosis (rare).
Why a species-specific page? Alprazolam pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.