Amitriptyline for Dog
Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Amitriptyline is used in dog for Separation anxiety, neuropathic pain. Routes documented in dog: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Amitriptyline in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Elavil
Dose ranges
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 1–4 mg/kg | q12-24h | Long-term (weeks-months) | Separation anxiety, neuropathic pain | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Mechanism of action
Inhibits reuptake of serotonin and norepinephrine. Also has anticholinergic, antihistaminic, and alpha-adrenergic blocking properties.
Side effects & warnings
Allow 2-4 weeks for behavioral effects. Sedation, dry mouth, urinary retention, constipation. CONTRAINDICATED with MAOIs. Serotonin syndrome risk with tramadol. Cardiotoxic in overdose.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Other Behavioral drugs with dog dosing
Amitriptyline dosing in other species
Why a species-specific page? Amitriptyline pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.