Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Fluoxetine is dosed at 1–2 mg/kg PO q24h in dogs, per RECONCILE - Fluoxetine Hydrochloride Tablet, Chewable [US Product Label for Dogs]. Pegasus Laboratories, Inc.; 2021. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=006035a8-b8da-47cb-924b-524c05da8641 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.575 (2026-08-01).. Fluoxetine is used in dogs for Separation anxiety, compulsive disorders. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Fluoxetine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Reconcile, Prozac
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 1–2 mg/kg | q24h | Long-term (months) | Separation anxiety, compulsive disorders | Strong |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Selectively inhibits serotonin reuptake at the presynaptic membrane, increasing serotonergic neurotransmission.
Reconcile FDA-approved for canine separation anxiety. 4-6 weeks for full effect. Serotonin syndrome risk with tramadol, MAOIs, TCAs. Reduced appetite, lethargy initially. Long half-life.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Fluoxetine dose range in dogs, with cited source references: PO 1–2 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Fluoxetine in dogs: PO.
Cited course lengths for Fluoxetine in dogs include: Long-term (months). Duration depends on the indication — match it to the specific dose rule in the table above.
Fluoxetine is indicated in dogs for: Separation anxiety, compulsive disorders.
These are general warnings for Fluoxetine across species; consult the dog dosing table above for species-specific guidance. Reconcile FDA-approved for canine separation anxiety. 4-6 weeks for full effect. Serotonin syndrome risk with tramadol, MAOIs, TCAs. Reduced appetite, lethargy initially. Long half-life.
Why a species-specific page? Fluoxetine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.