Fluoxetine for Dogs

Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg

Fluoxetine is dosed at 1–2 mg/kg PO q24h in dogs, per RECONCILE - Fluoxetine Hydrochloride Tablet, Chewable [US Product Label for Dogs]. Pegasus Laboratories, Inc.; 2021. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=006035a8-b8da-47cb-924b-524c05da8641 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.575 (2026-08-01). — Plumb's 10th ed (held) printed p.548, Fluoxetine monograph spanning p.547-548; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Fluoxetine is used in dogs for Separation anxiety, compulsive disorders. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Fluoxetine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.

US trade names: Reconcile, Prozac

Dose ranges

Route	Dose	Frequency	Duration	Indication	Evidence	Source
PO	1–2 mg/kg	q24h	Long-term (months)	Separation anxiety, compulsive disorders

What each reference text prints

Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.

Printed doses in mg/kg for this drug and species, by source
Dose (mg/kg)	Route	Source	As printed
1–2	PO	BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.188	1-2 mg/kg p.o. q24h
1–2	PO	Papich Saunders Handbook of Veterinary Drugs, 4th edp.369	• 1-2 mg/kg once daily PO.

Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.

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Side effects & warnings

Reconcile FDA-approved for canine separation anxiety. 4-6 weeks for full effect. Serotonin syndrome risk with tramadol, MAOIs, TCAs. Reduced appetite, lethargy initially. Long half-life.

Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.

Frequently asked questions

What is the dose of Fluoxetine for Dogs?

Fluoxetine dose range in dogs, with cited source references: PO 1–2 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.

How is Fluoxetine administered in Dogs?

Documented routes for Fluoxetine in dogs: PO.

How long is Fluoxetine given in Dogs?

Cited course lengths for Fluoxetine in dogs include: Long-term (months). Duration depends on the indication — match it to the specific dose rule in the table above.

What conditions does Fluoxetine treat in Dogs?

Fluoxetine is indicated in dogs for: Separation anxiety, compulsive disorders.

What are the side effects of Fluoxetine in Dogs?

These are general warnings for Fluoxetine across species; consult the dog dosing table above for species-specific guidance. Reconcile FDA-approved for canine separation anxiety. 4-6 weeks for full effect. Serotonin syndrome risk with tramadol, MAOIs, TCAs. Reduced appetite, lethargy initially. Long half-life.

Why a species-specific page? Fluoxetine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.