ExoticRx · exoticrx.com/drugs/fluoxetine
US brand names:Reconcile, Prozac
Fluoxetine is dosed at 1–5 mg/kg PO q12-24h in african grey parrots, per 221. Desmarchelier MR. Clinical psychopharmacology for the exotic animal practitioner. Vet Clin North Am Exot Anim Pract. 2021;24:17-35. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.472 doi:10.1016/j.cvex.2020.08.003 — Carpenter's Exotic Animal Formulary 6th ed, Table 5.10 (Psychotropic and Antiepileptic Agents Used in Birds.a,b). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929. Verify against current literature before clinical use.
Selectively inhibits serotonin reuptake at the presynaptic membrane, increasing serotonergic neurotransmission.
Reconcile FDA-approved for canine separation anxiety. 4-6 weeks for full effect. Serotonin syndrome risk with tramadol, MAOIs, TCAs. Reduced appetite, lethargy initially. Long half-life.
Species references:All African Grey Parrot drugsAll Cat (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 13 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 1–2 mg/kg | q24h | Strong | RECONCILE - Fluoxetine Hydrochloride Tablet, Chewable [US Product Label for Dogs]. Pegasus Laboratories, Inc.; 2021. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=006035a8-b8da-47cb-924b-524c05da8641 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.575 (2026-08-01). — Plumb's 10th ed (held) printed p.548, Fluoxetine monograph spanning p.547-548; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| Cat (Domestic) | PO | 0.5–1.5 mg/kg | q24h | Weak |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.
| Papich, Saunders Handbook of Veterinary Drugs, 5th Ed, printed p.341 (corpus page 369), Fluoxetine Hydrochloride > Small Animal Dosage > Cats — EDITION CORRECTED 2026-08-07: this citation named the 5th edition, which is not held. The page locator resolves in the 4th ed (2016), the copy actually consulted, and that page names the drug; the reference is to the 4th. — SOURCE EDITION: Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855 |