ExoticRx · exoticrx.com/drugs/fluoxetine
US brand names:Reconcile, Prozac
Fluoxetine is dosed at 1–2 mg/kg PO q24h in dogs, per RECONCILE - Fluoxetine Hydrochloride Tablet, Chewable [US Product Label for Dogs]. Pegasus Laboratories, Inc.; 2021. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=006035a8-b8da-47cb-924b-524c05da8641 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.575 (2026-08-01).. Verify against current literature before clinical use.
Selectively inhibits serotonin reuptake at the presynaptic membrane, increasing serotonergic neurotransmission.
Reconcile FDA-approved for canine separation anxiety. 4-6 weeks for full effect. Serotonin syndrome risk with tramadol, MAOIs, TCAs. Reduced appetite, lethargy initially. Long half-life.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 1–2 mg/kg | q24h | Strong | RECONCILE - Fluoxetine Hydrochloride Tablet, Chewable [US Product Label for Dogs]. Pegasus Laboratories, Inc.; 2021. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=006035a8-b8da-47cb-924b-524c05da8641 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.575 (2026-08-01). |
| Cat (Domestic) | PO | 0.5–1.5 mg/kg | q24h | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.