Cat · Felis catus · typical adult weight 2.50–7.00 kg
Diphenoxylate-Atropine is dosed at 0.05–0.1 mg/kg PO q12h in cats, per Marks SL. GI therapeutics: which ones and when? Presented at: International Veterinary Emergency and Critical Care Society; 2008. Distributed by John Wiley & Sons, Inc. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.440 (2026-08-01).. Diphenoxylate-Atropine is used in cats for Acute diarrhea. Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Diphenoxylate-Atropine in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Lomotil
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.05–0.1 mg/kg | q12h | Short-term only; 1-2 days | Acute diarrhea | Weak | Marks SL. GI therapeutics: which ones and when? Presented at: International Veterinary Emergency and Critical Care Society; 2008. Distributed by John Wiley & Sons, Inc. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.440 (2026-08-01). |
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These ranges are per kg. Enter your cat's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Diphenoxylate is a synthetic opioid (mu-receptor agonist) that slows GI motility. Combined with subtherapeutic atropine to discourage misuse.
May cause CNS depression at high doses. Avoid in infectious diarrhea. Atropine component may cause anticholinergic effects. Use cautiously in cats.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Diphenoxylate-Atropine dose range in cats, with cited source references: PO 0.05–0.1 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Diphenoxylate-Atropine in cats: PO.
Cited course lengths for Diphenoxylate-Atropine in cats include: Short-term only; 1-2 days. Duration depends on the indication — match it to the specific dose rule in the table above.
Diphenoxylate-Atropine is indicated in cats for: Acute diarrhea.
These are general warnings for Diphenoxylate-Atropine across species; consult the cat dosing table above for species-specific guidance. May cause CNS depression at high doses. Avoid in infectious diarrhea. Atropine component may cause anticholinergic effects. Use cautiously in cats.
Why a species-specific page? Diphenoxylate-Atropine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.