Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Diphenoxylate-Atropine is dosed at 0.05–0.1 mg/kg PO q8-12h in dogs, per Washabau R. The Colon: Dietary & medical management of colonic disease. Presented at: ACVIM Forum; 2005. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.440 (2026-08-01).. Diphenoxylate-Atropine is used in dogs for Acute non-infectious diarrhea. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Diphenoxylate-Atropine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Lomotil
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.05–0.1 mg/kg | q8-12h | Short-term only (2-3 days max) | Acute non-infectious diarrhea | Moderate | Washabau R. The Colon: Dietary & medical management of colonic disease. Presented at: ACVIM Forum; 2005. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.440 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Diphenoxylate is a synthetic opioid (mu-receptor agonist) that slows GI motility. Combined with subtherapeutic atropine to discourage misuse.
May cause CNS depression at high doses. Avoid in infectious diarrhea. Atropine component may cause anticholinergic effects. Use cautiously in cats.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Diphenoxylate-Atropine dose range in dogs, with cited source references: PO 0.05–0.1 mg/kg q8-12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Diphenoxylate-Atropine in dogs: PO.
Cited course lengths for Diphenoxylate-Atropine in dogs include: Short-term only (2-3 days max). Duration depends on the indication — match it to the specific dose rule in the table above.
Diphenoxylate-Atropine is indicated in dogs for: Acute non-infectious diarrhea.
These are general warnings for Diphenoxylate-Atropine across species; consult the dog dosing table above for species-specific guidance. May cause CNS depression at high doses. Avoid in infectious diarrhea. Atropine component may cause anticholinergic effects. Use cautiously in cats.
Why a species-specific page? Diphenoxylate-Atropine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.