Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Denamarin is dosed at 10–20 mg/kg SAMe component PO q24h on empty stomach in dogs, per Webster CRL, Center SA, Cullen JM, et al. ACVIM consensus statement on the diagnosis and treatment of chronic hepatitis in dogs. Journal of Veterinary Internal Medicine. 2019;33:1173-1200. doi:10.1111/jvim.15467 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1166 (2026-08-01).. Denamarin is used in dogs for Hepatic support / elevated liver enzymes. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Denamarin in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Denamarin
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 10–20 mg/kg SAMe component | q24h on empty stomach | Long-term hepatic support; minimum 30 days | Hepatic support / elevated liver enzymes | Moderate | Webster CRL, Center SA, Cullen JM, et al. ACVIM consensus statement on the diagnosis and treatment of chronic hepatitis in dogs. Journal of Veterinary Internal Medicine. 2019;33:1173-1200. doi:10.1111/jvim.15467 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1166 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Combines S-adenosylmethionine (SAMe) and silybin phosphatidylcholine. SAMe supports glutathione synthesis and hepatocyte repair; silybin provides antioxidant and anti-fibrotic effects.
Give on empty stomach. Generally well tolerated. Mild GI upset possible. Not a substitute for definitive hepatic therapy.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Denamarin dose range in dogs, with cited source references: PO 10–20 mg/kg SAMe component q24h on empty stomach. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Denamarin in dogs: PO.
Cited course lengths for Denamarin in dogs include: Long-term hepatic support; minimum 30 days. Duration depends on the indication — match it to the specific dose rule in the table above.
Denamarin is indicated in dogs for: Hepatic support / elevated liver enzymes.
These are general warnings for Denamarin across species; consult the dog dosing table above for species-specific guidance. Give on empty stomach. Generally well tolerated. Mild GI upset possible. Not a substitute for definitive hepatic therapy.
Why a species-specific page? Denamarin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.