ExoticRx · exoticrx.com/drugs/denamarin
US brand names:Denamarin
Denamarin is dosed at 10–20 mg/kg SAMe component PO q24h on empty stomach in dogs, per Webster CRL, Center SA, Cullen JM, et al. ACVIM consensus statement on the diagnosis and treatment of chronic hepatitis in dogs. Journal of Veterinary Internal Medicine. 2019;33:1173-1200. doi:10.1111/jvim.15467 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1166 (2026-08-01).. Verify against current literature before clinical use.
Combines S-adenosylmethionine (SAMe) and silybin phosphatidylcholine. SAMe supports glutathione synthesis and hepatocyte repair; silybin provides antioxidant and anti-fibrotic effects.
Give on empty stomach. Generally well tolerated. Mild GI upset possible. Not a substitute for definitive hepatic therapy.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 10–20 mg/kg SAMe component | q24h on empty stomach | Moderate | Webster CRL, Center SA, Cullen JM, et al. ACVIM consensus statement on the diagnosis and treatment of chronic hepatitis in dogs. Journal of Veterinary Internal Medicine. 2019;33:1173-1200. doi:10.1111/jvim.15467 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1166 (2026-08-01). |
| Cat (Domestic) | PO | 10–20 mg/kg SAMe component | q24h on empty stomach | Moderate | Center S. Update on Canine & Feline Liver Disease. Presented at: ECVIM; 2008. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1166 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.