Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Dirlotapide is dosed at 0.01–0.2 mg/kg PO q24h in dogs, per FDA label (Slentrol); Plumb's Veterinary Drug Handbook, 9th Ed; FDA openFDA Adverse Event Database. Dirlotapide is used in dogs for Obesity management. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Dirlotapide in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Slentrol
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.01–0.2 mg/kg | q24h | Up to 12 months; taper over 2-4 weeks when discontinuing | Obesity management | Strong | FDA label (Slentrol); Plumb's Veterinary Drug Handbook, 9th Ed; FDA openFDA Adverse Event Database |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Selectively inhibits microsomal triglyceride transfer protein in enterocytes, blocking fat absorption and triggering satiety signaling via peptide YY release, reducing appetite and food intake.
Vomiting and diarrhea are common (lipid malabsorption). Elevated liver enzymes possible. Must taper dose gradually when discontinuing. Weight regain occurs after discontinuation. Dogs only.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Dirlotapide dose range in dogs, with cited source references: PO 0.01–0.2 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Dirlotapide in dogs: PO.
Cited course lengths for Dirlotapide in dogs include: Up to 12 months; taper over 2-4 weeks when discontinuing. Duration depends on the indication — match it to the specific dose rule in the table above.
Dirlotapide is indicated in dogs for: Obesity management.
These are general warnings for Dirlotapide across species; consult the dog dosing table above for species-specific guidance. Vomiting and diarrhea are common (lipid malabsorption). Elevated liver enzymes possible. Must taper dose gradually when discontinuing. Weight regain occurs after discontinuation. Dogs only.
Why a species-specific page? Dirlotapide pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.