ExoticRx · exoticrx.com/drugs/dirlotapide
US brand names:Slentrol
Dirlotapide is dosed at 0.01–0.2 mg/kg PO q24h in dogs, per FDA label (Slentrol); Plumb's Veterinary Drug Handbook, 9th Ed; FDA openFDA Adverse Event Database. Verify against current literature before clinical use.
Selectively inhibits microsomal triglyceride transfer protein in enterocytes, blocking fat absorption and triggering satiety signaling via peptide YY release, reducing appetite and food intake.
Vomiting and diarrhea are common (lipid malabsorption). Elevated liver enzymes possible. Must taper dose gradually when discontinuing. Weight regain occurs after discontinuation. Dogs only.
Species references:All Dog (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 0.01–0.2 mg/kg | q24h | Strong | FDA label (Slentrol); Plumb's Veterinary Drug Handbook, 9th Ed; FDA openFDA Adverse Event Database |
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