Alosetron for Dog
Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Alosetron is used in dog for Severe diarrhea-predominant IBS. Routes documented in dog: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Alosetron in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Lotronex
Dose ranges
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.01–0.05 mg/kg | q12h | Investigational; short-term trial | Severe diarrhea-predominant IBS | Weak | Veterinary Gastroenterology Literature Review |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Mechanism of action
Selective serotonin 5-HT3 receptor antagonist that inhibits visceral afferent activity, reducing colonic motility and secretion.
Side effects & warnings
Risk of ischemic colitis and severe constipation. Very restricted use in human medicine. Minimal veterinary data — investigational only.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Other Gastrointestinal drugs with dog dosing
Alosetron dosing in other species
Why a species-specific page? Alosetron pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.