Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Aminopentamide is dosed at 0.01–0.03 mg/kg PO q8-12h in dogs, per Instructions for Use: "Dosing guidelines based on manufacturer’s recommendation." (Papich, Aminopentamide monograph, printed p.28) — Verified against Papich/Saunders Handbook of Veterinary Drugs, 4th Ed, p.56 (2026-08-01).. Aminopentamide is used in dogs for GI smooth muscle spasm, vomiting, diarrhea, GI smooth muscle spasm, vomiting when oral not feasible. Routes documented in dogs: PO, SC. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Aminopentamide in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Centrine
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.01–0.03 mg/kgmax 0.2 mg total | q8-12h | As needed; short-term use preferred | GI smooth muscle spasm, vomiting, diarrhea | Moderate | Instructions for Use: "Dosing guidelines based on manufacturer’s recommendation." (Papich, Aminopentamide monograph, printed p.28) — Verified against Papich/Saunders Handbook of Veterinary Drugs, 4th Ed, p.56 (2026-08-01). |
| SC | 0.01–0.03 mg/kgmax 0.2 mg total | q8-12h | Switch to oral when feasible | GI smooth muscle spasm, vomiting when oral not feasible | Moderate | Instructions for Use: "Dosing guidelines based on manufacturer’s recommendation." (Papich, Aminopentamide monograph, printed p.28) — Verified against Papich/Saunders Handbook of Veterinary Drugs, 4th Ed, p.56 (2026-08-01). |
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Anticholinergic (parasympatholytic) agent that reduces GI smooth muscle spasm by blocking muscarinic acetylcholine receptors in the GI tract, decreasing motility and secretions.
May cause anticholinergic side effects: dry mouth, urinary retention, tachycardia, mydriasis. Contraindicated in GI obstruction and glaucoma. Use cautiously in patients with cardiac disease.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Aminopentamide dose ranges in dogs, with cited source references: PO 0.01–0.03 mg/kg q8-12h; SC 0.01–0.03 mg/kg q8-12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Aminopentamide in dogs: PO, SC.
Cited course lengths for Aminopentamide in dogs include: As needed; short-term use preferred; Switch to oral when feasible. Duration depends on the indication — match it to the specific dose rule in the table above.
Aminopentamide is indicated in dogs for: GI smooth muscle spasm, vomiting, diarrhea, GI smooth muscle spasm, vomiting when oral not feasible.
These are general warnings for Aminopentamide across species; consult the dog dosing table above for species-specific guidance. May cause anticholinergic side effects: dry mouth, urinary retention, tachycardia, mydriasis. Contraindicated in GI obstruction and glaucoma. Use cautiously in patients with cardiac disease.
Why a species-specific page? Aminopentamide pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.