Aminopentamide for Dog
Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Aminopentamide is used in dog for GI smooth muscle spasm, vomiting, diarrhea, GI smooth muscle spasm, vomiting when oral not feasible. Routes documented in dog: PO, SC. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Aminopentamide in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Centrine
Dose ranges
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.01–0.03 mg/kg | q8-12h | As needed; short-term use preferred | GI smooth muscle spasm, vomiting, diarrhea | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed; FDA openFDA Adverse Event Database |
| SC | 0.01–0.03 mg/kg | q8-12h | Switch to oral when feasible | GI smooth muscle spasm, vomiting when oral not feasible | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed; FDA openFDA Adverse Event Database |
Absolute dose ceilings, regardless of body weight: 0.2 mg total (PO); 0.2 mg total (SC).
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Mechanism of action
Anticholinergic (parasympatholytic) agent that reduces GI smooth muscle spasm by blocking muscarinic acetylcholine receptors in the GI tract, decreasing motility and secretions.
Side effects & warnings
May cause anticholinergic side effects: dry mouth, urinary retention, tachycardia, mydriasis. Contraindicated in GI obstruction and glaucoma. Use cautiously in patients with cardiac disease.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Other Gastrointestinal drugs with dog dosing
Aminopentamide dosing in other species
Why a species-specific page? Aminopentamide pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.