Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Esomeprazole is dosed at 0.5–1 mg/kg IV q12-24h in dogs, per Kuhl A, Odunayo A, Price J, et al. Comparative analysis of the effect of IV administered acid suppressants on gastric pH in dogs. J Vet Intern Med. 2020;34(2):678-683. doi:10.1111/jvim.15718 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.507 (2026-08-01). — Plumb's 10th ed (held) printed p.480, Esomeprazole monograph spanning p.478-480; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Esomeprazole is used in dogs for Acute GI bleeding, stress ulceration, Gastric acid suppression. Routes documented in dogs: IV, PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Esomeprazole in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Nexium
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.5–1 mg/kg | q12-24h | Until oral PPI tolerated | Acute GI bleeding, stress ulceration | Moderate | Kuhl A, Odunayo A, Price J, et al. Comparative analysis of the effect of IV administered acid suppressants on gastric pH in dogs. J Vet Intern Med. 2020;34(2):678-683. doi:10.1111/jvim.15718 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.507 (2026-08-01). — Plumb's 10th ed (held) printed p.480, Esomeprazole monograph spanning p.478-480; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| PO | 1 mg/kg | q24h (on an empty stomach) | 2-8 weeks | Gastric acid suppression | Moderate | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted), Esomeprazole, Dosages, DOGS(b), printed p.480 (corpus PDF p.507), ref 2: Hwang JH, Jeong JW, Song GH, Koo TS, Seo KW. Pharmacokinetics and acid suppressant efficacy of esomeprazole after intravenous, oral, and subcutaneous administration to healthy beagle dogs. J Vet Intern Med. 2017;31(3):743-750. Concordant second text: Papich Handbook of Veterinary Drugs, 5th Ed, printed p.302 (PDF p.330): 'Dogs 20 mg/dog q24h PO or 1-2 mg/kg q24h PO; 1 mg/kg by IV injection.' — EDITION UNVERIFIABLE 2026-08-07: this citation names Papich 5th ed, which is NOT held. Its page locator does not resolve to a page naming this drug in the held 4th ed (2016), so the reference cannot be confirmed against any copy available here. Treat the page number as unchecked and consult the 5th edition directly. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207; Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855 |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
S-isomer of omeprazole. Irreversibly inhibits H+/K+ ATPase (proton pump) in gastric parietal cells. More predictable pharmacokinetics than omeprazole.
More bioavailable than omeprazole. IV form available for acute GI bleeding. Long-term use may affect calcium/magnesium absorption. Rebound acid hypersecretion on discontinuation.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Esomeprazole dose ranges in dogs, with cited source references: IV 0.5–1 mg/kg q12-24h; PO 1 mg/kg q24h (on an empty stomach). Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Esomeprazole in dogs: IV, PO.
Cited course lengths for Esomeprazole in dogs include: Until oral PPI tolerated; 2-8 weeks. Duration depends on the indication — match it to the specific dose rule in the table above.
Esomeprazole is indicated in dogs for: Acute GI bleeding, stress ulceration, Gastric acid suppression.
These are general warnings for Esomeprazole across species; consult the dog dosing table above for species-specific guidance. More bioavailable than omeprazole. IV form available for acute GI bleeding. Long-term use may affect calcium/magnesium absorption. Rebound acid hypersecretion on discontinuation.
Why a species-specific page? Esomeprazole pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.