Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Esomeprazole is dosed at 0.5–1 mg/kg IV q12-24h in dogs, per Kuhl A, Odunayo A, Price J, et al. Comparative analysis of the effect of IV administered acid suppressants on gastric pH in dogs. J Vet Intern Med. 2020;34(2):678-683. doi:10.1111/jvim.15718 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.507 (2026-08-01).. Esomeprazole is used in dogs for Acute GI bleeding, stress ulceration, Gastric acid suppression. Routes documented in dogs: IV, PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Esomeprazole in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Nexium
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.5–1 mg/kg | q12-24h | Until oral PPI tolerated | Acute GI bleeding, stress ulceration | Moderate | Kuhl A, Odunayo A, Price J, et al. Comparative analysis of the effect of IV administered acid suppressants on gastric pH in dogs. J Vet Intern Med. 2020;34(2):678-683. doi:10.1111/jvim.15718 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.507 (2026-08-01). |
| PO | 1 mg/kg | q24h (on an empty stomach) | 2-8 weeks | Gastric acid suppression | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed, Esomeprazole, Dosages, DOGS(b), printed p.480 (corpus PDF p.507), ref 2: Hwang JH, Jeong JW, Song GH, Koo TS, Seo KW. Pharmacokinetics and acid suppressant efficacy of esomeprazole after intravenous, oral, and subcutaneous administration to healthy beagle dogs. J Vet Intern Med. 2017;31(3):743-750. Concordant second text: Papich Handbook of Veterinary Drugs, 5th Ed, printed p.302 (PDF p.330): 'Dogs 20 mg/dog q24h PO or 1-2 mg/kg q24h PO; 1 mg/kg by IV injection.' |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
S-isomer of omeprazole. Irreversibly inhibits H+/K+ ATPase (proton pump) in gastric parietal cells. More predictable pharmacokinetics than omeprazole.
More bioavailable than omeprazole. IV form available for acute GI bleeding. Long-term use may affect calcium/magnesium absorption. Rebound acid hypersecretion on discontinuation.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Esomeprazole dose ranges in dogs, with cited source references: IV 0.5–1 mg/kg q12-24h; PO 1 mg/kg q24h (on an empty stomach). Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Esomeprazole in dogs: IV, PO.
Cited course lengths for Esomeprazole in dogs include: Until oral PPI tolerated; 2-8 weeks. Duration depends on the indication — match it to the specific dose rule in the table above.
Esomeprazole is indicated in dogs for: Acute GI bleeding, stress ulceration, Gastric acid suppression.
These are general warnings for Esomeprazole across species; consult the dog dosing table above for species-specific guidance. More bioavailable than omeprazole. IV form available for acute GI bleeding. Long-term use may affect calcium/magnesium absorption. Rebound acid hypersecretion on discontinuation.
Why a species-specific page? Esomeprazole pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.