ExoticRx · exoticrx.com/drugs/esomeprazole
US brand names:Nexium
Esomeprazole is dosed at 0.5–1 mg/kg IV q12-24h in dogs, per Kuhl A, Odunayo A, Price J, et al. Comparative analysis of the effect of IV administered acid suppressants on gastric pH in dogs. J Vet Intern Med. 2020;34(2):678-683. doi:10.1111/jvim.15718 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.507 (2026-08-01).. Verify against current literature before clinical use.
S-isomer of omeprazole. Irreversibly inhibits H+/K+ ATPase (proton pump) in gastric parietal cells. More predictable pharmacokinetics than omeprazole.
More bioavailable than omeprazole. IV form available for acute GI bleeding. Long-term use may affect calcium/magnesium absorption. Rebound acid hypersecretion on discontinuation.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 0.5–1 mg/kg | q12-24h | Moderate | Kuhl A, Odunayo A, Price J, et al. Comparative analysis of the effect of IV administered acid suppressants on gastric pH in dogs. J Vet Intern Med. 2020;34(2):678-683. doi:10.1111/jvim.15718 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.507 (2026-08-01). |
| Dog (Domestic) | PO | 0.5–1 mg/kg | q12-24h | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
Upgrade to Pro or Student to unlock the full dose ranges and frequency for every species. The drug's mechanism, warnings, indications, and cited sources are free to read.
View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.