Cat · Felis catus · typical adult weight 2.50–7.00 kg
Cisapride is dosed at 0.5–1 mg/kg PO q8h in cats, per LeGrange SN, Boothe DM, Herndon S, Willard MD. Pharmacokinetics and suggested oral dosing regimen of cisapride: A study in healthy cats. J Am Anim Hosp Assoc. 1997;33:517-523. doi:10.5326/15473317-33-6-517 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.297 (2026-08-01). — Plumb's 10th ed (held) printed p.269, Cisapride monograph spanning p.269-270; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Cisapride is used in cats for Chronic idiopathic constipation, Megacolon, constipation, gastroparesis, Post-anesthetic ileus, Megacolon, constipation (prokinetic). Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 4 cited dose rules for Cisapride in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Propulsid
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.5–1 mg/kg | q8h | Chronic; may lose efficacy over time | Chronic idiopathic constipation | Strong | LeGrange SN, Boothe DM, Herndon S, Willard MD. Pharmacokinetics and suggested oral dosing regimen of cisapride: A study in healthy cats. J Am Anim Hosp Assoc. 1997;33:517-523. doi:10.5326/15473317-33-6-517 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.297 (2026-08-01). — Plumb's 10th ed (held) printed p.269, Cisapride monograph spanning p.269-270; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| PO | 0.1–1 mg/kg | q8-12h | Chronic as needed | Megacolon, constipation, gastroparesis | Strong | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.269, Cisapride monograph spanning p.269-270; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| PO | 0.25–0.5 mg/kg | q8-12h | Until motility returns | Post-anesthetic ileus | Moderate | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.269, Cisapride monograph spanning p.269-270; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| PO | 0.5 mg/kg | q8-12h | Long-term | Megacolon, constipation (prokinetic) | Moderate | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.269, Cisapride monograph spanning p.269-270; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.5 | IM | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.104 | ested including 2.5-5.0 mg per cat p.o. 2-3 times daily and 0.5 mg/kg 2-3 times daily. Dosages may be titrated upwards, if tolerated, to as high as 7.5 mg |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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These ranges are per kg. Enter your cat's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Serotonin 5-HT4 receptor agonist. Enhances acetylcholine release in the myenteric plexus, promoting GI motility throughout the tract.
Withdrawn from human market (cardiac arrhythmias); available as compounded product for veterinary use. Contraindicated with GI obstruction. May interact with azole antifungals.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Cisapride dose ranges in cats, with cited source references: PO 0.5–1 mg/kg q8h; PO 0.1–1 mg/kg q8-12h; PO 0.25–0.5 mg/kg q8-12h; PO 0.5 mg/kg q8-12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Cisapride in cats: PO.
Cited course lengths for Cisapride in cats include: Chronic; may lose efficacy over time; Chronic as needed; Until motility returns; Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Cisapride is indicated in cats for: Chronic idiopathic constipation, Megacolon, constipation, gastroparesis, Post-anesthetic ileus, Megacolon, constipation (prokinetic).
These are general warnings for Cisapride across species; consult the cat dosing table above for species-specific guidance. Withdrawn from human market (cardiac arrhythmias); available as compounded product for veterinary use. Contraindicated with GI obstruction. May interact with azole antifungals.
Why a species-specific page? Cisapride pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.