Question 1

What is Cisapride used for?

Accepted Answer

Cisapride is indicated for: Chronic GI motility disorder, Chronic idiopathic constipation, constipation, constipation (prokinetic), Crop stasis, Gastroparesis, GI stasis, GI stasis (prokinetic), Megacolon, megaesophagus adjunct, Post-anesthetic GI stasis, Post-anesthetic ileus, Post-operative ileus, Refractory GI hypomotility.

Question 2

What routes can Cisapride be administered by?

Accepted Answer

Available routes: PO.

Question 3

Which species have cited Cisapride dosing data?

Accepted Answer

Cisapride dosing in the ExoticRx formulary covers 7 species: African Grey Parrot, Bearded Dragon, Cat (Domestic), Chinchilla, Dog (Domestic), Guinea Pig, Rabbit (Domestic).

Question 4

Is Cisapride a controlled substance?

Accepted Answer

Cisapride is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Cisapride?

Accepted Answer

Withdrawn from human market (cardiac arrhythmias); available as compounded product for veterinary use. Contraindicated with GI obstruction. May interact with azole antifungals.

Question 6

What are the side effects of Cisapride?

Accepted Answer

Reported side effects, adverse reactions, and contraindications for Cisapride: Withdrawn from human market (cardiac arrhythmias); available as compounded product for veterinary use. Contraindicated with GI obstruction. May interact with azole antifungals.

Question 7

How does Cisapride work?

Accepted Answer

Serotonin 5-HT4 receptor agonist. Enhances acetylcholine release in the myenteric plexus, promoting GI motility throughout the tract.

Species	Route	Dose	Frequency	Evidence	Source
Cat (Domestic)	PO	0.25–0.5 mg/kg	q8h	Moderate	Plumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)	PO	0.1–1 mg/kg	q8-12h	Strong	Plumb's Veterinary Drug Handbook, 9th Ed

Cisapride

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Cisapride dosing data (15 dose rules)

Evidence levels across 15 dose rules

Backed by 3 published sources

Sample dosing (2 of 15 cited rules)

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