ExoticRx · exoticrx.com/drugs/domperidone
US brand names:Motilium, Equidone
Domperidone is dosed at 0.1–0.3 mg/kg PO q8h in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Verify against current literature before clinical use.
Peripheral dopamine D2 receptor antagonist. Enhances GI motility and increases lower esophageal sphincter pressure. Also increases prolactin release.
Does not cross blood-brain barrier (fewer CNS effects than metoclopramide). QT prolongation risk. Used in horses for fescue toxicosis to restore lactation.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
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