ExoticRx · exoticrx.com/drugs/doramectin
US brand names:Dectomax
Doramectin is dosed at 0.2–0.5 mg/kg SC q7-14d x 2-3 treatments in chinchillas, per Beck W, Pantchev N. Praktische Parasitologie bei Heimtieren, Schluetersche Verlagsgesellschaft MBH & Co, Hannover, Germany; 2006. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.776 — Carpenter's Exotic Animal Formulary 6th ed, Table 9.2 (Antiparasitic Agents Used in Rodents). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929. Verify against current literature before clinical use.
Binds glutamate-gated chloride channels in invertebrate nerve/muscle cells, causing paralysis and death of parasites.
MDR1-sensitive breeds: CONTRAINDICATED (Collies, etc.). Long duration of action (single injection). Not for use in cats. Approved for cattle/swine — extra-label in small animals.
Species references:All Chinchilla drugsAll Degu drugsAll Dog (Domestic) drugsAll Dwarf Hamster drugsAll Guinea Pig drugsAll Mouse drugsAll Pet Rat drugsAll Rabbit (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 8 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | SC | 0.2–0.6 mg/kg | q7-14d | Moderate | Murayama N, Shibata K, Nagata M. Efficacy of weekly oral doramectin treatment in canine demodicosis. Vet Rec. 2010;167:63-64. doi:10.1136/vr.b4885; Upadhyay A, Srivastava M, Srivastava A, et al. Therapeutic potential of doramectin against canine sarcoptic mange. Journal of Entomology and Zoology Studies. 2019;7(4):403-407. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.452 (2026-08-01). — Plumb's 10th ed (held) printed p.424, Doramectin monograph spanning p.424-425; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 | ORIGINAL SOURCE THE BOOK CITES (2026-08-20): the dose row carries superscript 16 — "0.2 mg/kg weekly16 SC was given to alpacas, peak concentr" — which resolves in the monograph's own reference list to: Upadhyay A, Srivastava M, Srivastava A, et al. Therapeutic potential of doramectin against canine sarcoptic mange. Journal of Entomology and Zoology Studies. 2019;7(4):403-407. This records what the handbook attributes the figure to. It is NOT a statement that the reference was read or that it validates the dose. |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.