ExoticRx · exoticrx.com/drugs/doramectin
US brand names:Dectomax
Doramectin is dosed at 0.2 mg/kg IM once in rabbits, per Kanbur M, Atalay O, Ica A, et al. The curative and antioxidative efficiency of doramectin and doramectin+vitamin AD3E treatment on Psoroptes cuniculi infestation in rabbits. Res Vet Sci. 2008;85:291-293. | Plumb's Veterinary Drug Handbook, 10th ed (2023) — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.849 — Plumb's 10th ed printed p.424, Doramectin monograph spanning p.424-425. — Carpenter's Exotic Animal Formulary 6th ed, Table 10.3 (Antiparasitic Agents Used in Rabbits.a). Verify against current literature before clinical use.
Binds glutamate-gated chloride channels in invertebrate nerve/muscle cells, causing paralysis and death of parasites.
MDR1-sensitive breeds: CONTRAINDICATED (Collies, etc.). Long duration of action (single injection). Not for use in cats. Approved for cattle/swine — extra-label in small animals.
Species references:All Chinchilla drugsAll Degu drugsAll Dog (Domestic) drugsAll Dwarf Hamster drugsAll Guinea Pig drugsAll Mouse drugsAll Pet Rat drugsAll Rabbit (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 8 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | SC | 0.2–0.6 mg/kg | q7-14d | Moderate | Murayama N, Shibata K, Nagata M. Efficacy of weekly oral doramectin treatment in canine demodicosis. Vet Rec. 2010;167:63-64. doi:10.1136/vr.b4885; Upadhyay A, Srivastava M, Srivastava A, et al. Therapeutic potential of doramectin against canine sarcoptic mange. Journal of Entomology and Zoology Studies. 2019;7(4):403-407. — Plumb's 10th ed printed p.424, Doramectin monograph spanning p.424-425. | ORIGINAL SOURCE THE BOOK CITES (2026-08-20): the dose row carries superscript 16 — "0.2 mg/kg weekly16 SC was given to alpacas, peak concentr" — which resolves in the monograph's own reference list to: Upadhyay A, Srivastava M, Srivastava A, et al. Therapeutic potential of doramectin against canine sarcoptic mange. Journal of Entomology and Zoology Studies. 2019;7(4):403-407. This records what the handbook attributes the figure to. It is NOT a statement that the reference was read or that it validates the dose. |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.