ExoticRx · exoticrx.com/drugs/emodepside
US brand names:Profender(combination)
Emodepside is dosed at 3 mg/kg TOPICAL Single application in cats, per Profender - 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4h-pyrazino(2,1-a)isoquinolin-4-one, emodepside solution for cats [US product label]. In: Elanco; 2021. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=31f0a4ec-2a29-4de5-971b-633e109b276d — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.471 (2026-08-01).. Verify against current literature before clinical use.
Stimulates presynaptic secretin receptors (SLO-1 potassium channels) in nematodes, causing paralysis. Novel mechanism unrelated to other anthelmintics.
Topical formulation for cats. Do not allow oral ingestion of topical product (salivation, vomiting). Novel anthelmintic class with activity against some resistant nematodes.
Species references:All Cat (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | TOPICAL | 3 mg/kg | Single application | Strong | Profender - 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4h-pyrazino(2,1-a)isoquinolin-4-one, emodepside solution for cats [US product label]. In: Elanco; 2021. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=31f0a4ec-2a29-4de5-971b-633e109b276d — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.471 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.