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Emodepside Oral

Profender Oral

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Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Antiparasitic

Routes

PO

Indications

Nematode infectionsNematode infections (multi-drug resistant)

Mechanism of Action

Acts on latrophilin receptors (SLO-1 K+ channels) in nematode neuromuscular junction, causing flaccid paralysis. Novel mechanism without cross-resistance to other anthelmintics.

Side effects & warnings

Generally well tolerated. Effective against larval stages. Some strains of ivermectin-resistant parasites remain susceptible. P-glycoprotein substrate.

Species with Emodepside Oral dosing data (2 dose rules)

Cat (Domestic)Dog (Domestic)

Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs

Evidence levels across 2 dose rules

Moderate×2

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published source

  • · BSAVA Small Animal Formulary, 10th Ed

Sample dosing (2 of 2 cited rules)

A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)PO0.45 mg/kgSingle doseModerateBSAVA Small Animal Formulary, 10th Ed
Cat (Domestic)PO0.45 mg/kgSingle doseModerateBSAVA Small Animal Formulary, 10th Ed

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