ExoticRx · exoticrx.com/drugs/emodepside-topical
US brand names:Profender(component)
Emodepside Topical is dosed at 3 mg/kg Topical once in cats, per Profender - 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4h-pyrazino(2,1-a)isoquinolin-4-one, emodepside solution for cats [US product label]. In: Elanco; 2021. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=31f0a4ec-2a29-4de5-971b-633e109b276d — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.471 (2026-08-01).. Verify against current literature before clinical use.
Depsipeptide activating presynaptic latrophilin receptors and SLO-1 potassium channels causing paralysis and death of nematodes and cestodes.
Combined with praziquantel in Profender (cats). Topical application. Do not allow oral ingestion. Salivation if cat licks application site. Effective against roundworms, hookworms, tapeworms.
Species references:All Cat (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | Topical | 3 mg/kg | once | Strong | Profender - 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4h-pyrazino(2,1-a)isoquinolin-4-one, emodepside solution for cats [US product label]. In: Elanco; 2021. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=31f0a4ec-2a29-4de5-971b-633e109b276d — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.471 (2026-08-01). |
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