Pocket Pet · Cavia porcellus · typical adult weight 0.70–1.20 kg
Enrofloxacin is dosed at 5–10 mg/kg IM q12h in guinea pigs, per Adamcak A, Otten B. Rodent therapeutics. Vet Clin North Am Exot Anim Pract. 2000;3:221-237.; Meredith A. BSAVA Small Animal Formulary: Part B: Exotic Pets, British Small Animal Veterinary Association, Quedgeley, Gloucester, UK; 2015.; Morrisey JK, Carpenter JW. Formulary. In: Quesenberry KE, Carpenter JW, eds. Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery, 4th ed., Elsevier, St. Louis, MO; 2021:620-630. — Verified against Carpenter's Exotic Animal Formulary, 6th Ed, p.771 (2026-08-01).. Enrofloxacin is used in guinea pigs for Bacterial infections, Respiratory infections (Bordetella, Streptococcus), Streptococcus equi subsp. zooepidemicus. Routes documented in guinea pigs: IM, PO, SC. A typical adult guinea pig weighs 0.70–1.20 kg. ExoticRx lists 5 cited dose rules for Enrofloxacin in guinea pigs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Baytril
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IM | 5–10 mg/kg | q12h | 7-14 days | Bacterial infections | Moderate | Adamcak A, Otten B. Rodent therapeutics. Vet Clin North Am Exot Anim Pract. 2000;3:221-237.; Meredith A. BSAVA Small Animal Formulary: Part B: Exotic Pets, British Small Animal Veterinary Association, Quedgeley, Gloucester, UK; 2015.; Morrisey JK, Carpenter JW. Formulary. In: Quesenberry KE, Carpenter JW, eds. Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery, 4th ed., Elsevier, St. Louis, MO; 2021:620-630. — Verified against Carpenter's Exotic Animal Formulary, 6th Ed, p.771 (2026-08-01). |
| PO | 5–10 mg/kg | q12h | 10-14 days | Respiratory infections (Bordetella, Streptococcus) | Moderate | Meredith A. BSAVA Small Animal Formulary: Part B: Exotic Pets, British Small Animal Veterinary Association, Quedgeley, Gloucester, UK; 2015. — Verified against Carpenter's Exotic Animal Formulary, 6th Ed, p.771 (2026-08-01). |
| PO | 5–10 mg/kg | q12h | 7-14 days | Bacterial infections | Moderate | Adamcak A, Otten B. Rodent therapeutics. Vet Clin North Am Exot Anim Pract. 2000;3:221-237.; Meredith A. BSAVA Small Animal Formulary: Part B: Exotic Pets, British Small Animal Veterinary Association, Quedgeley, Gloucester, UK; 2015.; Morrisey JK, Carpenter JW. Formulary. In: Quesenberry KE, Carpenter JW, eds. Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery, 4th ed., Elsevier, St. Louis, MO; 2021:620-630. — Verified against Carpenter's Exotic Animal Formulary, 6th Ed, p.771 (2026-08-01). |
| PO | 10–20 mg/kg | q12h | 14-21 days | Streptococcus equi subsp. zooepidemicus | Moderate | Adamcak A, Otten B. Rodent therapeutics. Vet Clin North Am Exot Anim Pract. 2000;3:221-237.; Meredith A. BSAVA Small Animal Formulary: Part B: Exotic Pets, British Small Animal Veterinary Association, Quedgeley, Gloucester, UK; 2015.; Morrisey JK, Carpenter JW. Formulary. In: Quesenberry KE, Carpenter JW, eds. Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery, 4th ed., Elsevier, St. Louis, MO; 2021:620-630. — Verified against Carpenter's Exotic Animal Formulary, 6th Ed, p.771 (2026-08-01). |
| SC | 5–10 mg/kg | q12h | 7-14 days | Bacterial infections | Moderate | Morrisey JK, Carpenter JW. Formulary. In: Quesenberry KE, Carpenter JW, eds. Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery, 4th ed., Elsevier, St. Louis, MO; 2021:620-630. — Verified against Carpenter's Exotic Animal Formulary, 6th Ed, p.771 (2026-08-01). |
Need the exact dose for your patient?
These ranges are per kg. Enter your guinea pig's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription.
Avoid in growing animals (cartilage damage). Do NOT use in cats at doses >5mg/kg (retinal toxicity). Avoid concurrent use with theophylline.
Species-specific contraindications and adverse-reaction reports for guinea pigs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Enrofloxacin dose ranges in guinea pigs, with cited source references: IM 5–10 mg/kg q12h; PO 5–10 mg/kg q12h; PO 5–10 mg/kg q12h; PO 10–20 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Enrofloxacin in guinea pigs: IM, PO, SC.
Cited course lengths for Enrofloxacin in guinea pigs include: 7-14 days; 10-14 days; 14-21 days. Duration depends on the indication — match it to the specific dose rule in the table above.
Enrofloxacin is indicated in guinea pigs for: Bacterial infections, Respiratory infections (Bordetella, Streptococcus), Streptococcus equi subsp. zooepidemicus.
These are general warnings for Enrofloxacin across species; consult the guinea pig dosing table above for species-specific guidance. Avoid in growing animals (cartilage damage). Do NOT use in cats at doses >5mg/kg (retinal toxicity). Avoid concurrent use with theophylline.
Why a species-specific page? Enrofloxacin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in guinea pigs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.