Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Estradiol is dosed at 0.02 mg/kg IM once q14-28 days in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Estradiol is used in dogs for Estrogen-responsive urinary incontinence (LOW DOSE). Routes documented in dogs: IM. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Estradiol in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: ECP, Depo-Estradiol
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IM | 0.02 mg/kg | once q14-28 days | Long-term at lowest dose | Estrogen-responsive urinary incontinence (LOW DOSE) | Weak | Plumb's Veterinary Drug Handbook, 9th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Natural estrogen binding estrogen receptors. Stimulates reproductive tract and secondary sex characteristics. Dose-dependent bone marrow effects.
APLASTIC ANEMIA at misbreeding-prevention doses — potentially fatal. Dogs extremely sensitive. Never use for mismating prevention. Bone marrow suppression is dose-dependent and irreversible.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Estradiol dose range in dogs, with cited source references: IM 0.02 mg/kg once q14-28 days. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Estradiol in dogs: IM.
Cited course lengths for Estradiol in dogs include: Long-term at lowest dose. Duration depends on the indication — match it to the specific dose rule in the table above.
Estradiol is indicated in dogs for: Estrogen-responsive urinary incontinence (LOW DOSE).
These are general warnings for Estradiol across species; consult the dog dosing table above for species-specific guidance. APLASTIC ANEMIA at misbreeding-prevention doses — potentially fatal. Dogs extremely sensitive. Never use for mismating prevention. Bone marrow suppression is dose-dependent and irreversible.
Why a species-specific page? Estradiol pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.