ExoticRx · exoticrx.com/drugs/felbamate
US brand names:Felbatol
Felbamate is dosed at 15–30 mg/kg PO q8h in dogs, per Ruehlmann D, Podell M, March P. Treatment of partial seizures and seizure-like activity with felbamate in six dogs. J Small Anim Pract. 2001;42(8):403-408. doi:10.1111/j.1748-5827.2001.tb02490.x — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.531 (2026-08-01).. Verify against current literature before clinical use.
Dual mechanism: blocks NMDA receptor glycine recognition site and enhances GABA-A receptor function. Also blocks voltage-dependent sodium channels.
Risk of aplastic anemia and hepatotoxicity in humans — monitor CBC and liver enzymes. Veterinary use for refractory epilepsy. Drug interactions with phenobarbital and other AEDs.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 15–30 mg/kg | q8h | Weak | Ruehlmann D, Podell M, March P. Treatment of partial seizures and seizure-like activity with felbamate in six dogs. J Small Anim Pract. 2001;42(8):403-408. doi:10.1111/j.1748-5827.2001.tb02490.x — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.531 (2026-08-01). |
| Cat (Domestic) | PO | 10–20 mg/kg | q8h-q12h | Anecdotal | Plumb's Veterinary Drug Handbook, 9th Ed |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.