ExoticRx · exoticrx.com/drugs/fipronil-s-methoprene
US brand names:Frontline Plus
Contraindicated in Rabbit
Fipronil blocks GABA-gated chloride channels in arthropod CNS; S-methoprene is an insect growth regulator (IGR) preventing flea egg/larval development.
Dogs and cats. Monthly topical. TOXIC to rabbits. Do not use on rabbits. Keep away from aquatic environments. Apply to dry skin.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | TOPICAL | Monthly topical for cats | q30 days | Strong | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1481 (2026-08-01). |
| Dog (Domestic) | TOPICAL | Monthly topical | q30 days | Strong | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1481 (2026-08-01). |
Upgrade to Pro or Student to unlock the full dose ranges and frequency for every species. The drug's mechanism, warnings, indications, and cited sources are free to read.
View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.