Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Fipronil-S-Methoprene is used in dogs for Fleas and ticks. Routes documented in dogs: TOPICAL. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Fipronil-S-Methoprene in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Frontline Plus
Contraindicated in Rabbit
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| TOPICAL | Monthly topical | q30 days | Monthly | Fleas and ticks | Strong | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1481 (2026-08-01). |
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Enter your dog's weight to check these cited ranges in the calculator — unit and concentration math done for you.
Fipronil blocks GABA-gated chloride channels in arthropod CNS; S-methoprene is an insect growth regulator (IGR) preventing flea egg/larval development.
Dogs and cats. Monthly topical. TOXIC to rabbits. Do not use on rabbits. Keep away from aquatic environments. Apply to dry skin.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Fipronil-S-Methoprene dose range in dogs, with cited source references: TOPICAL Monthly topical q30 days. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Fipronil-S-Methoprene in dogs: TOPICAL.
Cited course lengths for Fipronil-S-Methoprene in dogs include: Monthly. Duration depends on the indication — match it to the specific dose rule in the table above.
Fipronil-S-Methoprene is indicated in dogs for: Fleas and ticks.
These are general warnings for Fipronil-S-Methoprene across species; consult the dog dosing table above for species-specific guidance. Dogs and cats. Monthly topical. TOXIC to rabbits. Do not use on rabbits. Keep away from aquatic environments. Apply to dry skin.
Why a species-specific page? Fipronil-S-Methoprene pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.