Cat · Felis catus · typical adult weight 2.50–7.00 kg
Hydrochlorothiazide is dosed at 1–2 mg/kg PO q12h in cats, per Kittleson M. Therapy of Heart Failure. In: Ettinger S, Feldman E, eds. Textbook of Veterinary Internal Medicine: Diseases of the Dog and Cat. Vol 1. WB Saunders; 2000:713-737. PMID: 42533713 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.638 (2026-08-01). — Plumb's 10th ed (held) printed p.611, Hydrochlorothiazide monograph spanning p.610-611; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Hydrochlorothiazide is used in cats for Calcium oxalate stone prevention. Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Hydrochlorothiazide in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: HydroDiuril, Microzide
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 1–2 mg/kg | q12h | Long-term | Calcium oxalate stone prevention | Moderate | Kittleson M. Therapy of Heart Failure. In: Ettinger S, Feldman E, eds. Textbook of Veterinary Internal Medicine: Diseases of the Dog and Cat. Vol 1. WB Saunders; 2000:713-737. PMID: 42533713 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.638 (2026-08-01). — Plumb's 10th ed (held) printed p.611, Hydrochlorothiazide monograph spanning p.610-611; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 1–2 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.212 | 1-2 mg/kg p.o. q12-24h. Start at low dose and titrate upwards cautiously as above. |
| 2–4 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.406 | • 2-4 mg/kg q12h PO. • To decrease excretion of calcium in |
| 1 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.406 | urine: 1 mg/kg q12h PO. |
| 1–2 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.406 | • Congestive heart failure: 1-2 mg/kg |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Inhibits sodium-chloride cotransporter in distal convoluted tubule. Reduces renal calcium excretion (useful in calcium oxalate stone prevention).
Hypokalemia, hyponatremia risk. Monitor electrolytes. Less potent diuretic than furosemide. Used with furosemide for diuretic resistance.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Hydrochlorothiazide dose range in cats, with cited source references: PO 1–2 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Hydrochlorothiazide in cats: PO.
Cited course lengths for Hydrochlorothiazide in cats include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Hydrochlorothiazide is indicated in cats for: Calcium oxalate stone prevention.
These are general warnings for Hydrochlorothiazide across species; consult the cat dosing table above for species-specific guidance. Hypokalemia, hyponatremia risk. Monitor electrolytes. Less potent diuretic than furosemide. Used with furosemide for diuretic resistance.
Why a species-specific page? Hydrochlorothiazide pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.