ExoticRx · exoticrx.com/drugs/hydrochlorothiazide
US brand names:HydroDiuril, Microzide
Hydrochlorothiazide is dosed at 1 mg/kg PO q24-72h in bearded dragons, per 106. Divers SJ. Clinician's approach to renal disease in lizards. Proc Annu Conf Assoc Rept Amph Vet; 1997:5- — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.273 — Carpenter's Exotic Animal Formulary 6th ed, Table 4.11 (Miscellaneous Agents Used in Reptiles). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929 — ROUTE SOURCE (wave 3, two readers): the route is NOT printed on the Carpenter row. It is decided by BSAVA Small Animal Formulary 10th ed, Part B — Exotic Pets, printed p.172 — "DOSES / Reptiles: 1 mg/kg p.o. q24-72h." Mader's p.1420 carries the identical row but its superscript resolves to the same Divers 1997 ARAV paper as Carpenter reference 106, so it is one lineage and not a second source.. Verify against current literature before clinical use.
Inhibits sodium-chloride cotransporter in distal convoluted tubule. Reduces renal calcium excretion (useful in calcium oxalate stone prevention).
Hypokalemia, hyponatremia risk. Monitor electrolytes. Less potent diuretic than furosemide. Used with furosemide for diuretic resistance.
Species references:All Bearded Dragon drugsAll Cat (Domestic) drugsAll Dog (Domestic) drugsAll Rabbit (Domestic) drugsAll Veiled Chameleon drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 5 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 1–4 mg/kg | q12h | Moderate | Boswood A. Heart failure: clinical management. In: Ettinger S, Feldman E, Cote E, eds. Textbook of Veterinary Internal Medicine: Diseases of the Dog and Cat. 8th ed. Elsevier; 2017:1163-1176. PMID: 42524781 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.638 (2026-08-01). — Plumb's 10th ed (held) printed p.610, Hydrochlorothiazide monograph spanning p.610-611; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| Cat (Domestic) | PO | 1–2 mg/kg | q12h | Moderate |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.
| Kittleson M. Therapy of Heart Failure. In: Ettinger S, Feldman E, eds. Textbook of Veterinary Internal Medicine: Diseases of the Dog and Cat. Vol 1. WB Saunders; 2000:713-737. PMID: 42533713 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.638 (2026-08-01). — Plumb's 10th ed (held) printed p.611, Hydrochlorothiazide monograph spanning p.610-611; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |