Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Hydrochlorothiazide is dosed at 1–4 mg/kg PO q12h in dogs, per Boswood A. Heart failure: clinical management. In: Ettinger S, Feldman E, Cote E, eds. Textbook of Veterinary Internal Medicine: Diseases of the Dog and Cat. 8th ed. Elsevier; 2017:1163-1176. PMID: 42524781 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.638 (2026-08-01).. Hydrochlorothiazide is used in dogs for Edema, hypertension, calcium oxalate stone prevention. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Hydrochlorothiazide in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: HydroDiuril, Microzide
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 1–4 mg/kg | q12h | Long-term | Edema, hypertension, calcium oxalate stone prevention | Moderate |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits sodium-chloride cotransporter in distal convoluted tubule. Reduces renal calcium excretion (useful in calcium oxalate stone prevention).
Hypokalemia, hyponatremia risk. Monitor electrolytes. Less potent diuretic than furosemide. Used with furosemide for diuretic resistance.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Hydrochlorothiazide dose range in dogs, with cited source references: PO 1–4 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Hydrochlorothiazide in dogs: PO.
Cited course lengths for Hydrochlorothiazide in dogs include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Hydrochlorothiazide is indicated in dogs for: Edema, hypertension, calcium oxalate stone prevention.
These are general warnings for Hydrochlorothiazide across species; consult the dog dosing table above for species-specific guidance. Hypokalemia, hyponatremia risk. Monitor electrolytes. Less potent diuretic than furosemide. Used with furosemide for diuretic resistance.
Why a species-specific page? Hydrochlorothiazide pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.