Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Hydrochlorothiazide is dosed at 1–4 mg/kg PO q12h in dogs, per Boswood A. Heart failure: clinical management. In: Ettinger S, Feldman E, Cote E, eds. Textbook of Veterinary Internal Medicine: Diseases of the Dog and Cat. 8th ed. Elsevier; 2017:1163-1176. PMID: 42524781 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.638 (2026-08-01). — Plumb's 10th ed (held) printed p.610, Hydrochlorothiazide monograph spanning p.610-611; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Hydrochlorothiazide is used in dogs for Edema, hypertension, calcium oxalate stone prevention. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Hydrochlorothiazide in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: HydroDiuril, Microzide
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 1–4 mg/kg | q12h | Long-term | Edema, hypertension, calcium oxalate stone prevention | Moderate | Boswood A. Heart failure: clinical management. In: Ettinger S, Feldman E, Cote E, eds. Textbook of Veterinary Internal Medicine: Diseases of the Dog and Cat. 8th ed. Elsevier; 2017:1163-1176. PMID: 42524781 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.638 (2026-08-01). — Plumb's 10th ed (held) printed p.610, Hydrochlorothiazide monograph spanning p.610-611; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.5–4 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.212 | 0.5-4 mg/kg p.o. q12-24h. Start at low dose and titrate upwards every 5-10 days, to effect. Monitor u |
| 2–4 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.406 | • 2-4 mg/kg q12h PO. • To decrease excretion of calcium in |
| 1 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.406 | urine: 1 mg/kg q12h PO. |
| 1–2 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.406 | • Congestive heart failure: 1-2 mg/kg |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits sodium-chloride cotransporter in distal convoluted tubule. Reduces renal calcium excretion (useful in calcium oxalate stone prevention).
Hypokalemia, hyponatremia risk. Monitor electrolytes. Less potent diuretic than furosemide. Used with furosemide for diuretic resistance.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Hydrochlorothiazide dose range in dogs, with cited source references: PO 1–4 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Hydrochlorothiazide in dogs: PO.
Cited course lengths for Hydrochlorothiazide in dogs include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Hydrochlorothiazide is indicated in dogs for: Edema, hypertension, calcium oxalate stone prevention.
These are general warnings for Hydrochlorothiazide across species; consult the dog dosing table above for species-specific guidance. Hypokalemia, hyponatremia risk. Monitor electrolytes. Less potent diuretic than furosemide. Used with furosemide for diuretic resistance.
Why a species-specific page? Hydrochlorothiazide pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| 0.5 |
| PO |
| Papich Saunders Handbook of Veterinary Drugs, 4th edp.408 |
| • Antitussive dose: 0.5 mg/kg q8 hr PO. Increase the dose if needed for tracheal |
| 1.5 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.408 | collapse in dogs, but not above the dose of 1.5 mg/kg. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.