ExoticRx · exoticrx.com/drugs/imidacloprid-moxidectin-topical
US brand names:Advantage Multi
Imidacloprid-Moxidectin Topical is dosed at 0.2 ml/kg topical q14d x 3 treatments in bearded dragons, per 170. Groza A, Mederle N, Darabus G. Advocate- therapeutical solution in parasitical infestation in frillneck lizard (Chlamydosaurus kingii) and bearded dragon (Pogona vitticeps). Lucrari Stiintifice - Universitatea Stiinte Agricole Banatului. Timisoara Med Vet. 2009;42:105-108. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.226 — Carpenter's Exotic Animal Formulary 6th ed, Table 4.4 (Antiparasitic Agents Used in Reptiles). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929. Verify against current literature before clinical use.
Imidacloprid (neonicotinoid) disrupts nicotinic acetylcholine transmission in fleas; moxidectin targets glutamate-gated chloride channels in nematodes. Heartworm prevention plus flea control.
Available for dogs and cats. Monthly topical. Do not allow ingestion. Keep treated animals separated until dry. Not for rabbits (ferrets have specific formulation).
Species references:All African Pygmy Hedgehog drugsAll Bearded Dragon drugsAll Cat (Domestic) drugsAll Crested Gecko drugsAll Dog (Domestic) drugsAll Leopard Gecko drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 6 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | TOPICAL | Do not use on rabbits | q30 days | Strong | ADVANTAGE MULTI FOR DOGS - Imidacloprid, Moxidectin Solution [US Product Label for Dogs]. Elanco US, Inc.; 2021. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3fc1a42b-6576-4890-aa0c-5c0eb903c85a — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.942 (2026-08-01). — Plumb's 10th ed (held) printed p.912, Moxidectin/Moxidectin Combination Products monograph spanning p.912-917; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| Cat (Domestic) | TOPICAL | See the cited source for the printed regimen | q30 days |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.
| ADVANTAGE MULTI FOR CATS - Imidacloprid, Moxidectin Solution [US Product Label for Cats and Ferrets]. Elanco US, Inc.; 2021. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4acea077-3f1a-4507-ab8c-2f65d9035c97 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.943 (2026-08-01). — Plumb's 10th ed (held) printed p.912, Moxidectin/Moxidectin Combination Products monograph spanning p.912-917; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |