ExoticRx · exoticrx.com/drugs/imidacloprid-moxidectin-topical
US brand names:Advantage Multi
Imidacloprid (neonicotinoid) disrupts nicotinic acetylcholine transmission in fleas; moxidectin targets glutamate-gated chloride channels in nematodes. Heartworm prevention plus flea control.
Available for dogs and cats. Monthly topical. Do not allow ingestion. Keep treated animals separated until dry. Not for rabbits (ferrets have specific formulation).
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | TOPICAL | Monthly topical | q30 days | Strong | ADVANTAGE MULTI FOR DOGS - Imidacloprid, Moxidectin Solution [US Product Label for Dogs]. Elanco US, Inc.; 2021. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3fc1a42b-6576-4890-aa0c-5c0eb903c85a — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.942 (2026-08-01). |
| Cat (Domestic) | TOPICAL | FDA-approved for cats | q30 days | Strong | ADVANTAGE MULTI FOR CATS - Imidacloprid, Moxidectin Solution [US Product Label for Cats and Ferrets]. Elanco US, Inc.; 2021. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4acea077-3f1a-4507-ab8c-2f65d9035c97 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.943 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.