Cat · Felis catus · typical adult weight 2.50–7.00 kg
Insulin Lispro is dosed at 0.05–0.1 IU/kg/hr IV Continuous IV infusion (CRI) in cats, per Malerba E, Mazzarino M, Baldo FD, et al. Use of lispro insulin for treatment of diabetic ketoacidosis in cats. J Feline Med Surg. 2019;21(2):115-123. doi:10.1177/1098612x18761696; Anderson JD, Rondeau DA, Hess RS. Lispro insulin and electrolyte supplementation for treatment of diabetic ketoacidosis in cats. J Vet Intern Med. 2019;33(4):1593-1601. doi:10.1111/jvim.15518 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.695 (2026-08-01).. Insulin Lispro is used in cats for Diabetic ketoacidosis (DKA). Routes documented in cats: IV. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Insulin Lispro in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Humalog
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.05–0.1 IU/kg/hr | Continuous IV infusion (CRI) | Until DKA resolves; transition to SC insulin | Diabetic ketoacidosis (DKA) |
| Moderate |
| Malerba E, Mazzarino M, Baldo FD, et al. Use of lispro insulin for treatment of diabetic ketoacidosis in cats. J Feline Med Surg. 2019;21(2):115-123. doi:10.1177/1098612x18761696; Anderson JD, Rondeau DA, Hess RS. Lispro insulin and electrolyte supplementation for treatment of diabetic ketoacidosis in cats. J Vet Intern Med. 2019;33(4):1593-1601. doi:10.1111/jvim.15518 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.695 (2026-08-01). |
One of the cited rules is a continuous-rate-infusion regimen: IV 0.05–0.1 IU/kg/hr Continuous IV infusion (CRI). CRI regimens are delivered as a continuous infusion rather than discrete doses — verify the rate against the cited source before use.
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Rapid-acting insulin analogue with reversed proline-lysine sequence at B28-B29, reducing self-association and enabling faster absorption.
Rapid onset — hypoglycemia risk if food not available. Used for DKA management or post-prandial glucose control. Short duration of action.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Insulin Lispro dose range in cats, with cited source references: IV 0.05–0.1 IU/kg/hr Continuous IV infusion (CRI). Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Insulin Lispro in cats: IV.
Cited course lengths for Insulin Lispro in cats include: Until DKA resolves; transition to SC insulin. Duration depends on the indication — match it to the specific dose rule in the table above.
Insulin Lispro is indicated in cats for: Diabetic ketoacidosis (DKA).
These are general warnings for Insulin Lispro across species; consult the cat dosing table above for species-specific guidance. Rapid onset — hypoglycemia risk if food not available. Used for DKA management or post-prandial glucose control. Short duration of action.
Why a species-specific page? Insulin Lispro pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.