Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Insulin Lispro is dosed at 0.05–0.1 IU/kg/hr IV Continuous IV infusion (CRI) in dogs, per Sears KW, Drobatz KJ, Hess RS. Use of lispro insulin for treatment of diabetic ketoacidosis in dogs. J Vet Emerg Crit Care. 2012;22(2):211-218. doi:10.1111/j.1476-4431.2012.00719.x; Nelson RW. Diabetic ketoacidosis. In: Feldman E, Nelson R, Reusch C, Scott-Moncrieff J, eds. Canine and Feline Endocrinology. 4th ed. Elsevier; 2015:315-347. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.694 (2026-08-01).. Insulin Lispro is used in dogs for Diabetic ketoacidosis (DKA). Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Insulin Lispro in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Humalog
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.05–0.1 IU/kg/hr | Continuous IV infusion (CRI) | Until DKA resolves; transition to SC insulin | Diabetic ketoacidosis (DKA) | Moderate | Sears KW, Drobatz KJ, Hess RS. Use of lispro insulin for treatment of diabetic ketoacidosis in dogs. J Vet Emerg Crit Care. 2012;22(2):211-218. doi:10.1111/j.1476-4431.2012.00719.x; Nelson RW. Diabetic ketoacidosis. In: Feldman E, Nelson R, Reusch C, Scott-Moncrieff J, eds. Canine and Feline Endocrinology. 4th ed. Elsevier; 2015:315-347. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.694 (2026-08-01). |
One of the cited rules is a continuous-rate-infusion regimen: IV 0.05–0.1 IU/kg/hr Continuous IV infusion (CRI). CRI regimens are delivered as a continuous infusion rather than discrete doses — verify the rate against the cited source before use.
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Rapid-acting insulin analogue with reversed proline-lysine sequence at B28-B29, reducing self-association and enabling faster absorption.
Rapid onset — hypoglycemia risk if food not available. Used for DKA management or post-prandial glucose control. Short duration of action.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Insulin Lispro dose range in dogs, with cited source references: IV 0.05–0.1 IU/kg/hr Continuous IV infusion (CRI). Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Insulin Lispro in dogs: IV.
Cited course lengths for Insulin Lispro in dogs include: Until DKA resolves; transition to SC insulin. Duration depends on the indication — match it to the specific dose rule in the table above.
Insulin Lispro is indicated in dogs for: Diabetic ketoacidosis (DKA).
These are general warnings for Insulin Lispro across species; consult the dog dosing table above for species-specific guidance. Rapid onset — hypoglycemia risk if food not available. Used for DKA management or post-prandial glucose control. Short duration of action.
Why a species-specific page? Insulin Lispro pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.