Insulin Lispro for Dog
Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Insulin Lispro is used in dog for Diabetic ketoacidosis (DKA). Routes documented in dog: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Insulin Lispro in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Humalog
Dose ranges
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.05–0.1 IU/kg/hr | Continuous IV infusion (CRI) | Until DKA resolves; transition to SC insulin | Diabetic ketoacidosis (DKA) | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
Continuous-rate infusion (CRI) in dog
One of the cited rules is a continuous-rate-infusion regimen: IV 0.05–0.1 IU/kg/hr Continuous IV infusion (CRI). CRI regimens are delivered as a continuous infusion rather than discrete doses — verify the rate against the cited source before use.
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Mechanism of action
Rapid-acting insulin analogue with reversed proline-lysine sequence at B28-B29, reducing self-association and enabling faster absorption.
Side effects & warnings
Rapid onset — hypoglycemia risk if food not available. Used for DKA management or post-prandial glucose control. Short duration of action.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Other Endocrine drugs with dog dosing
Insulin Lispro dosing in other species
Why a species-specific page? Insulin Lispro pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.