ExoticRx · exoticrx.com/drugs/insulin-lispro
US brand names:Humalog
Insulin Lispro is dosed at 0.05–0.1 IU/kg/hr IV Continuous IV infusion (CRI) in cats, per Malerba E, Mazzarino M, Baldo FD, et al. Use of lispro insulin for treatment of diabetic ketoacidosis in cats. J Feline Med Surg. 2019;21(2):115-123. doi:10.1177/1098612x18761696; Anderson JD, Rondeau DA, Hess RS. Lispro insulin and electrolyte supplementation for treatment of diabetic ketoacidosis in cats. J Vet Intern Med. 2019;33(4):1593-1601. doi:10.1111/jvim.15518 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.695 (2026-08-01). — Plumb's 10th ed (held) printed p.666, Insulin, Lispro monograph spanning p.666-669; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Verify against current literature before clinical use.
Rapid-acting insulin analogue with reversed proline-lysine sequence at B28-B29, reducing self-association and enabling faster absorption.
Rapid onset — hypoglycemia risk if food not available. Used for DKA management or post-prandial glucose control. Short duration of action.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Insulin Lispro CRI dose rules from the ExoticRx formulary. Verify against current literature before clinical use; CRI rates differ from bolus dosing and route, dilution, and monitoring matter. Sign in for the complete per-species CRI protocol set.
| Species | Route | Rate | Indication | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | IV | 0.05–0.1 IU/kg/hrContinuous IV infusion (CRI) | Diabetic ketoacidosis (DKA) | Moderate | Malerba E, Mazzarino M, Baldo FD, et al. Use of lispro insulin for treatment of diabetic ketoacidosis in cats. J Feline Med Surg. 2019;21(2):115-123. doi:10.1177/1098612x18761696; Anderson JD, Rondeau DA, Hess RS. Lispro insulin and electrolyte supplementation for treatment of diabetic ketoacidosis in cats. J Vet Intern Med. 2019;33(4):1593-1601. doi:10.1111/jvim.15518 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.695 (2026-08-01). — Plumb's 10th ed (held) printed p.666, Insulin, Lispro monograph spanning p.666-669; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| Dog (Domestic) |
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | IV | 0.05–0.1 IU/kg/hr | Continuous IV infusion (CRI) | Moderate | Malerba E, Mazzarino M, Baldo FD, et al. Use of lispro insulin for treatment of diabetic ketoacidosis in cats. J Feline Med Surg. 2019;21(2):115-123. doi:10.1177/1098612x18761696; Anderson JD, Rondeau DA, Hess RS. Lispro insulin and electrolyte supplementation for treatment of diabetic ketoacidosis in cats. J Vet Intern Med. 2019;33(4):1593-1601. doi:10.1111/jvim.15518 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.695 (2026-08-01). — Plumb's 10th ed (held) printed p.666, Insulin, Lispro monograph spanning p.666-669; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| Dog (Domestic) | IV | 0.05–0.1 IU/kg/hr |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.
| IV |
| 0.05–0.1 IU/kg/hrContinuous IV infusion (CRI) |
| Diabetic ketoacidosis (DKA) |
| Moderate |
| Sears KW, Drobatz KJ, Hess RS. Use of lispro insulin for treatment of diabetic ketoacidosis in dogs. J Vet Emerg Crit Care. 2012;22(2):211-218. doi:10.1111/j.1476-4431.2012.00719.x; Nelson RW. Diabetic ketoacidosis. In: Feldman E, Nelson R, Reusch C, Scott-Moncrieff J, eds. Canine and Feline Endocrinology. 4th ed. Elsevier; 2015:315-347. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.694 (2026-08-01). — Plumb's 10th ed (held) printed p.666, Insulin, Lispro monograph spanning p.666-669; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — figure located 2026-08-05 at Plumb's 10th ed printed p.651, Insulin, Aspart monograph; the page cited previously does not carry it. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Diabetic ketoacidosis (DKA)
Diabetic ketoacidosis (DKA)
| Continuous IV infusion (CRI) |
| Moderate |
| Sears KW, Drobatz KJ, Hess RS. Use of lispro insulin for treatment of diabetic ketoacidosis in dogs. J Vet Emerg Crit Care. 2012;22(2):211-218. doi:10.1111/j.1476-4431.2012.00719.x; Nelson RW. Diabetic ketoacidosis. In: Feldman E, Nelson R, Reusch C, Scott-Moncrieff J, eds. Canine and Feline Endocrinology. 4th ed. Elsevier; 2015:315-347. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.694 (2026-08-01). — Plumb's 10th ed (held) printed p.666, Insulin, Lispro monograph spanning p.666-669; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — figure located 2026-08-05 at Plumb's 10th ed printed p.651, Insulin, Aspart monograph; the page cited previously does not carry it. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |