ExoticRx · exoticrx.com/drugs/isosorbide-dinitrate
US brand names:Isordil, Dilatrate
Isosorbide Dinitrate is dosed at 0.5–2 mg/kg PO q8-12h in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Verify against current literature before clinical use.
Organic nitrate that releases nitric oxide, causing venodilation primarily and some arteriolar dilation, reducing preload and myocardial oxygen demand.
Tolerance develops with continuous use — nitrate-free interval recommended. Hypotension risk. Headache common.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 0.5–2 mg/kg | q8-12h | Weak | Plumb's Veterinary Drug Handbook, 9th Ed |
| Cat (Domestic) | PO | 0.5–1 mg/kg | q12h | Extrapolated | Verified against Papich/Saunders Handbook of Veterinary Drugs, 4th Ed, p.443 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.