Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Isotretinoin is used in dog for Sebaceous adenitis / idiopathic seborrhea, Intracutaneous cornifying epithelioma. Routes documented in dog: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Isotretinoin in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Accutane, Claravis
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 1–2 mg/kg | q12h-q24h | 3-4 month trial; chronic in some cases | Sebaceous adenitis / idiopathic seborrhea | Moderate | Miller WH, Small Animal Dermatology, 7th Ed |
| PO | 1–2 mg/kg | q24h | Chronic use; monitor lipids and liver quarterly | Intracutaneous cornifying epithelioma | Moderate | Miller WH, Small Animal Dermatology, 7th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
13-cis-retinoic acid that decreases sebaceous gland size and sebum production. Normalizes follicular keratinization and has anti-inflammatory effects.
Highly teratogenic — do not use in pregnant or breeding animals. Causes keratoconjunctivitis sicca, hepatotoxicity, and hyperostosis. Monitor tear production, liver enzymes, and triglycerides.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Isotretinoin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.