What is Levofloxacin used for?

Levofloxacin is indicated for: Respiratory/urinary infections.

Which species have cited Levofloxacin dosing data?

Levofloxacin dosing in the ExoticRx formulary covers 1 species: Dog (Domestic).

Is Levofloxacin a controlled substance?

Levofloxacin is not federally scheduled in the US. Controlled-drug status differs by country — verify your local rules.

What are the side effects of Levofloxacin?

Reported side effects, adverse reactions, and contraindications for Levofloxacin: Avoid in young growing animals. CNS effects possible. May prolong QT interval. Limited veterinary pharmacokinetic data.

Levofloxacin

US brand names:Levaquin

Calculate dosage

Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Levofloxacin is dosed at 5–10 mg/kg PO q24h in dogs, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.1378, Levofloxacin Ophthalmic monograph; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Verify against current literature before clinical use.

Drug Class

Antibiotic

Routes

POIV

Indications

Respiratory/urinary infections

Mechanism of Action

L-isomer of ofloxacin. Inhibits DNA gyrase and topoisomerase IV. Enhanced gram-positive activity compared to ciprofloxacin.

Side effects & warnings

Avoid in young growing animals. CNS effects possible. May prolong QT interval. Limited veterinary pharmacokinetic data.

Species with Levofloxacin dosing data (1 dose rule)

Dog (Domestic)

Species references:All Dog (Domestic) drugs

Evidence levels across 1 dose rule

Weak×1

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published source

· Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.1378, Levofloxacin Ophthalmic monograph; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207

Sample dosing (1 of 1 cited rule)

A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	5–10 mg/kg	q24h	Weak	Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.1378, Levofloxacin Ophthalmic monograph; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207

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Calculate Dosage for Levofloxacin