What is Linaclotide used for?

Linaclotide is indicated for: Chronic constipation, megacolon.

Which species have cited Linaclotide dosing data?

Linaclotide dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Is Linaclotide a controlled substance?

Linaclotide is not federally scheduled in the US. Controlled-drug status differs by country — verify your local rules.

What are the side effects of Linaclotide?

Reported side effects, adverse reactions, and contraindications for Linaclotide: Diarrhea is most common side effect. Not absorbed systemically. Minimal veterinary data — experimental use only.

Linaclotide

US brand names:Linzess

Calculate dosage

Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Linaclotide is dosed at 0.003–0.01 mg/kg PO q24h in dogs, per Source not established. The citation previously shown here named no retrievable document; a literature search on 2026-07-31 found no source that states this dose for this species and route. Treat as unverified and confirm against a primary reference before clinical use.. Verify against current literature before clinical use.

Drug Class

Gastrointestinal

Routes

Indications

Chronic constipationmegacolon

Mechanism of Action

Guanylate cyclase-C agonist that increases cyclic GMP, stimulating intestinal chloride and bicarbonate secretion, accelerating transit and reducing visceral pain.

Side effects & warnings

Diarrhea is most common side effect. Not absorbed systemically. Minimal veterinary data — experimental use only.

Species with Linaclotide dosing data (2 dose rules)

Cat (Domestic)Dog (Domestic)

Species references:All Cat (Domestic) drugs All Dog (Domestic) drugs

Evidence levels across 2 dose rules

Extrapolated×2

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published source

· Source not established. The citation previously shown here named no retrievable document; a literature search on 2026-07-31 found no source that states this dose for this species and route. Treat as unverified and confirm against a primary reference before clinical use.

Sample dosing (2 of 2 cited rules)

A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	0.003–0.01 mg/kg	q24h	Extrapolated	Source not established. The citation previously shown here named no retrievable document; a literature search on 2026-07-31 found no source that states this dose for this species and route. Treat as unverified and confirm against a primary reference before clinical use.
Cat (Domestic)	PO	0.003–0.01 mg/kg	q24h	Extrapolated	Source not established. The citation previously shown here named no retrievable document; a literature search on 2026-07-31 found no source that states this dose for this species and route. Treat as unverified and confirm against a primary reference before clinical use.

Report an error in this entry

Upgrade for Full Details

Upgrade to Pro or Student to unlock the full dose ranges and frequency for every species. The drug's mechanism, warnings, indications, and cited sources are free to read.

View Plans

Calculate Dosage for Linaclotide