ExoticRx · exoticrx.com/drugs/lubiprostone
US brand names:Amitiza
Lubiprostone is dosed at 3–6 mcg/kg PO q12h in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Verify against current literature before clinical use.
Activates type 2 chloride channels (ClC-2) in intestinal epithelium, increasing intestinal fluid secretion and promoting motility.
Used for chronic constipation. Nausea common. Limited veterinary data. Take with food. Contraindicated with mechanical GI obstruction.
Species references:All Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 3–6 mcg/kg | q12h | Weak | Plumb's Veterinary Drug Handbook, 9th Ed |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.