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Memantine

Namenda

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Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Neurological

Routes

PO

Indications

Cognitive dysfunction syndrome (investigational)

Mechanism of Action

Non-competitive NMDA glutamate receptor antagonist. Blocks pathological sustained NMDA activation while allowing normal synaptic transmission.

Side effects & warnings

Limited veterinary data. Investigated for cognitive dysfunction syndrome in dogs. May cause restlessness, GI upset. Renal elimination — adjust in renal disease.

Species with Memantine dosing data (1 dose rule)

Dog (Domestic)

Species references:All Dog (Domestic) drugs

Evidence levels across 1 dose rule

Weak×1

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published source

  • · Plumb's Veterinary Drug Handbook, 9th Ed

Sample dosing (1 of 1 cited rule)

A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)PO0.3–1 mg/kgq12hWeakPlumb's Veterinary Drug Handbook, 9th Ed

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